Literature DB >> 34839398

Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues.

Catarina L Nunes1, Filipe Jesus1, Ruben Francisco1, Catarina N Matias2,3, Moonseong Heo4, Steven B Heymsfield5, Anja Bosy-Westphal6, Luis B Sardinha1, Paulo Martins7, Cláudia S Minderico1, Analiza M Silva8.   

Abstract

PURPOSE: The aim of this study was (1) to assess AT through 13 different mathematical approaches and to compare their results; and (2) to understand if AT occurs after moderate WL.
METHODS: Ninety-four participants [mean (SD); BMI, 31.1 (4.3) kg/m2; age, 43.0 (9.4) years; 34% females] underwent a 1-year lifestyle intervention (clinicaltrials.gov ID: NCT03031951) and were randomized to intervention (IG, n = 49) or control groups (CG, n = 45), and all measurements were made at baseline and after 4 months. Fat mass (FM) and fat-free mass (FFM) were measured by dual-energy X-ray absorptiometry and REE by indirect calorimetry. AT was assessed through 13 different approaches, varying in how REE was predicted and/or how AT was assessed.
RESULTS: IG underwent a mean negative energy balance (EB) of 270 (289) kcal/day, p < 0.001), resulting in a WL of - 4.8 (4.9)% and an FM loss of - 11.3 (10.8)%. Regardless of approach, AT occurred in the IG, ranging from ~ - 65 to ~ - 230 kcal/day and three approaches showed significant AT in the CG.
CONCLUSIONS: Regardless of approach, AT occurred after moderate WL in the IG. AT assessment should be standardized and comparisons among studies with different methodologies to assess AT must be avoided.
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.

Entities:  

Keywords:  Energy balance; Metabolic adaptation; Metabolic slowing; Resting energy expenditure

Mesh:

Year:  2021        PMID: 34839398     DOI: 10.1007/s00394-021-02742-6

Source DB:  PubMed          Journal:  Eur J Nutr        ISSN: 1436-6207            Impact factor:   5.614


  48 in total

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3.  A study of weight regulation in the adult human body during over-nutrition. 1922.

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Review 4.  Why do individuals not lose more weight from an exercise intervention at a defined dose? An energy balance analysis.

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Review 5.  Effectiveness of weight loss interventions for obese older adults.

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Review 8.  Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis.

Authors:  Chenhan Ma; Alison Avenell; Mark Bolland; Jemma Hudson; Fiona Stewart; Clare Robertson; Pawana Sharma; Cynthia Fraser; Graeme MacLennan
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Review 9.  Attenuating the Biologic Drive for Weight Regain Following Weight Loss: Must What Goes Down Always Go Back Up?

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10.  Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype.

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  2 in total

1.  Effects of a 4-month active weight loss phase followed by weight loss maintenance on adaptive thermogenesis in resting energy expenditure in former elite athletes.

Authors:  Catarina L Nunes; Filipe Jesus; Ruben Francisco; Mark Hopkins; Luís B Sardinha; Paulo Martins; Cláudia S Minderico; Analiza M Silva
Journal:  Eur J Nutr       Date:  2022-07-14       Impact factor: 4.865

2.  Effect of a Personalized Diet to Reduce Postprandial Glycemic Response vs a Low-fat Diet on Weight Loss in Adults With Abnormal Glucose Metabolism and Obesity: A Randomized Clinical Trial.

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Journal:  JAMA Netw Open       Date:  2022-09-01
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