Literature DB >> 34835969

Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates.

Nasreddine El Omari1, Saad Bakrim2, Mohamed Bakha3, José M Lorenzo4,5, Maksim Rebezov6,7,8, Mohammad Ali Shariati7,8, Sara Aboulaghras9, Abdelaali Balahbib10, Mars Khayrullin8, Abdelhakim Bouyahya11.   

Abstract

Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but also epigenetic disturbances which are linked to it and which can induce transcriptional instability. Indeed, the involvement of epigenetic disturbances in cancer has been the subject of correlations today, in addition to the use of drugs that operate specifically on different epigenetic pathways. Natural molecules, especially those isolated from medicinal plants, have shown anticancer effects linked to mechanisms of action. The objective of this review is to explore the anticancer effects of alkaloids, terpenoids, quinones, and isothiocyanates.

Entities:  

Keywords:  DNMT; cancer; epidrugs; epigenetic; natural compounds

Mesh：

Substances：

Year:  2021        PMID： 34835969      PMCID： PMC8621755          DOI： 10.3390/nu13113714

Source DB:  PubMed          Journal:  Nutrients        ISSN： 2072-6643            Impact factor:   5.717


  166 in total

1.  Triterpenoid corosolic acid modulates global CpG methylation and transcriptome of tumor promotor TPA induced mouse epidermal JB6 P+ cells.

Authors:  Rasika R Hudlikar; Davit Sargsyan; Renyi Wu; Shan Su; Meinizi Zheng; Ah-Ng Kong
Journal:  Chem Biol Interact       Date:  2020-03-03       Impact factor: 5.192

Review 2.  Epigenetic regulation and cancer (review).

Authors:  Q W Chen; X Y Zhu; Y Y Li; Z Q Meng
Journal:  Oncol Rep       Date:  2013-12-11       Impact factor: 3.906

3.  Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms.

Authors:  Kendra J Royston; Bidisha Paul; Susan Nozell; Rajani Rajbhandari; Trygve O Tollefsbol
Journal:  Exp Cell Res       Date:  2018-04-22       Impact factor: 3.905

4.  Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells.

Authors:  Katarzyna Lubecka-Pietruszewska; Agnieszka Kaufman-Szymczyk; Barbara Stefanska; Barbara Cebula-Obrzut; Piotr Smolewski; Krystyna Fabianowska-Majewska
Journal:  J Nutrigenet Nutrigenomics       Date:  2015

5.  Temporal Efficacy of a Sulforaphane-Based Broccoli Sprout Diet in Prevention of Breast Cancer through Modulation of Epigenetic Mechanisms.

Authors:  Yuanyuan Li; Phillip Buckhaults; Shizhao Li; Trygve Tollefsbol
Journal:  Cancer Prev Res (Phila)       Date:  2018-05-15

6.  Harmine: evaluation of its antileishmanial properties in various vesicular delivery systems.

Authors:  Sanchaita Lala; Swapan Pramanick; Sibabrata Mukhopadhyay; Santu Bandyopadhyay; Mukul Kumar Basu
Journal:  J Drug Target       Date:  2004-04       Impact factor: 5.121

7.  Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.

Authors:  Jiuxia Pang; Na Shen; Fei Yan; Na Zhao; Liping Dou; Lai-Chu Wu; Christopher L Seiler; Li Yu; Ke Yang; Veronika Bachanova; Eric Weaver; Natalia Y Tretyakova; Shujun Liu
Journal:  Oncotarget       Date:  2017-05-23

8.  Clofarabine‑phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase‑dependent apoptosis.

Authors:  Agnieszka Kaufman-Szymczyk; Katarzyna Majda; Agata Szuławska-Mroczek; Krystyna Fabianowska-Majewska; Katarzyna Lubecka
Journal:  Mol Med Rep       Date:  2019-08-27       Impact factor: 2.952

9.  Solamargine inhibits gastric cancer progression by regulating the expression of lncNEAT1_2 via the MAPK signaling pathway.

Authors:  Runjia Fu; Xiaohong Wang; Ying Hu; Hong Du; Bin Dong; Sheng Ao; Li Zhang; Zhijian Sun; Lianhai Zhang; Guoqing Lv; Jiafu Ji
Journal:  Int J Oncol       Date:  2019-03-12       Impact factor: 5.650

10.  Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner.

Authors:  Takouhie Mgrditchian; Tsolere Arakelian; Jérôme Paggetti; Muhammad Zaeem Noman; Elodie Viry; Etienne Moussay; Kris Van Moer; Stephanie Kreis; Coralie Guerin; Stephanie Buart; Caroline Robert; Christophe Borg; Philippe Vielh; Salem Chouaib; Guy Berchem; Bassam Janji
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-16       Impact factor: 11.205
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  4 in total

1.  Antioxidant, Antidiabetic, and Antibacterial Potentials and Chemical Composition of Salvia officinalis and Mentha suaveolens Grown Wild in Morocco.

Authors:  Samiah Hamad Al-Mijalli; Hamza Assaggaf; Ahmed Qasem; Adel G El-Shemi; Emad M Abdallah; Hanae Naceiri Mrabti; Abdelhakim Bouyahya
Journal:  Adv Pharmacol Pharm Sci       Date:  2022-06-15

Review 2.  Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates.

Authors:  Abdelhakim Bouyahya; Naoufal El Hachlafi; Tarik Aanniz; Ilhame Bourais; Hamza Mechchate; Taoufiq Benali; Mohammad Ali Shariati; Pavel Burkov; José M Lorenzo; Polrat Wilairatana; Mohammad S Mubarak; Nasreddine El Omari
Journal:  Molecules       Date:  2022-04-15       Impact factor: 4.927

Review 3.  The Role of Epigenetic Modifications in Human Cancers and the Use of Natural Compounds as Epidrugs: Mechanistic Pathways and Pharmacodynamic Actions.

Authors:  Abdelhakim Bouyahya; Hamza Mechchate; Loubna Oumeslakht; Ikrame Zeouk; Sara Aboulaghras; Abdelaali Balahbib; Gokhan Zengin; Mohammad Amjad Kamal; Monica Gallo; Domenico Montesano; Nasreddine El Omari
Journal:  Biomolecules       Date:  2022-02-25

Review 4.  Health Benefits and Pharmacological Properties of Carvone.

Authors:  Abdelhakim Bouyahya; Hamza Mechchate; Taoufiq Benali; Rokia Ghchime; Saoulajan Charfi; Abdelaali Balahbib; Pavel Burkov; Mohammad Ali Shariati; Jose M Lorenzo; Nasreddine El Omari
Journal:  Biomolecules       Date:  2021-12-01
  4 in total

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