Clyve Yu Leon Yaow1, Seth En Teoh1, Wei Shyann Lim1, Renaeta Shi Qi Wang1, Ming Xuan Han2, Pin Pin Pek3, Benjamin Yong-Qiang Tan4, Marcus Eng Hock Ong5, Qin Xiang Ng6, Andrew Fu Wah Ho7. 1. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 10 Medical Dr, Singapore 117597, Singapore. 2. Department of Community Emergency Health and Paramedic Practice, Monash University, Melbourne, Australia, Building H McMahons Road, Frankston, Vic 3199, Australia. 3. Health Services and Systems Research, Duke-NUS Medical School, Singapore, 8 College Rd, Singapore 169857, Singapore. 4. Division of Neurology, Department of Medicine, National University Health System, Singapore, 1E Kent Ridge Rd, Singapore 119228, Singapore. 5. Department of Emergency Medicine, Singapore General Hospital, Singapore; Health Services & Systems Research, Singapore, 1 Outram Rd, Singapore 169608, Singapore; Duke-NUS Medical School, 8 College Rd, Singapore 169857, Singapore. 6. Emergency Medical Services Department, Singapore Civil Defence Force, Singapore, 91 Ubi Ave 4, Singapore 408827, Singapore. 7. Department of Emergency Medicine, Singapore General Hospital, Singapore; Pre-hospital and Emergency Research Centre, 1 Outram Rd, Singapore 169608, Singapore; Duke-NUS Medical School, 8 College Rd, Singapore 169857, Singapore. Electronic address: andrew.ho@duke-nus.edu.sg.
Abstract
AIM: Quality of life after surviving out-of-hospital cardiac arrest (OHCA) is poorly understood, and the risk to mental health is not well understood. We aimed to estimate the prevalence of anxiety, depression, and post-traumatic stress disorder (PTSD) following OHCA. METHODS: In this systematic review and meta-analysis, databases (MEDLINE, EMBASE, and PsycINFO) were searched from inception to July 3, 2021, for studies reporting the prevalence of depression, anxiety, and PTSD among OHCA survivors. Data abstraction and quality assessment were conducted by two authors independently, and a third resolved discrepancies. A single-arm meta-analysis of proportions was conducted to pool the proportion of patients with these conditions at the earliest follow-up time point in each study and at predefined time points. Meta-regression was performed to identify significant moderators that contributed to between-study heterogeneity. RESULTS: The search yielded 15,366 articles. 13 articles were included for analysis, which comprised 186,160 patients. The pooled overall prevalence at the earliest time point of follow-up was 19.0% (11 studies; 95% confidence interval [CI] = 11.0-30.0%) for depression, 26.0% (nine studies; 95% CI = 16.0-39.0%) for anxiety, and 20.0% (three studies; 95% CI = 3.0-65.0%) for PTSD. Meta-regression showed that the age of patients and proportion of female sex were non-significant moderators. CONCLUSION: The burden of mental health disorders is high among survivors of OHCA. There is an urgent need to understand the predisposing risk factors and develop preventive strategies.
AIM: Quality of life after surviving out-of-hospital cardiac arrest (OHCA) is poorly understood, and the risk to mental health is not well understood. We aimed to estimate the prevalence of anxiety, depression, and post-traumatic stress disorder (PTSD) following OHCA. METHODS: In this systematic review and meta-analysis, databases (MEDLINE, EMBASE, and PsycINFO) were searched from inception to July 3, 2021, for studies reporting the prevalence of depression, anxiety, and PTSD among OHCA survivors. Data abstraction and quality assessment were conducted by two authors independently, and a third resolved discrepancies. A single-arm meta-analysis of proportions was conducted to pool the proportion of patients with these conditions at the earliest follow-up time point in each study and at predefined time points. Meta-regression was performed to identify significant moderators that contributed to between-study heterogeneity. RESULTS: The search yielded 15,366 articles. 13 articles were included for analysis, which comprised 186,160 patients. The pooled overall prevalence at the earliest time point of follow-up was 19.0% (11 studies; 95% confidence interval [CI] = 11.0-30.0%) for depression, 26.0% (nine studies; 95% CI = 16.0-39.0%) for anxiety, and 20.0% (three studies; 95% CI = 3.0-65.0%) for PTSD. Meta-regression showed that the age of patients and proportion of female sex were non-significant moderators. CONCLUSION: The burden of mental health disorders is high among survivors of OHCA. There is an urgent need to understand the predisposing risk factors and develop preventive strategies.
Authors: Amelia Xin Chun Goh; Jie Cong Seow; Melvin Yong Hao Lai; Nan Liu; Yi Man Goh; Marcus Eng Hock Ong; Shir Lynn Lim; Jamie Sin Ying Ho; Jun Wei Yeo; Andrew Fu Wah Ho Journal: JAMA Netw Open Date: 2022-05-02
Authors: Zi Hui Celeste Ng; Siyuan Joseph Ho; Tan Caleb; Clyve Yu Leon Yaow; Seth En Teoh; Lai Peng Tham; Marcus Eng Hock Ong; Shu-Ling Chong; Andrew Fu Wah Ho Journal: J Clin Med Date: 2022-08-26 Impact factor: 4.964