PURPOSE: This study intends to add to previous reports on acute corneal graft rejection following anti-severe acute respiratory syndrome-coronavirus-2 vaccination, providing data to corroborate a possible causative relationship between anti-COVID-19 immunization and corneal graft rejection, regardless of vaccine or graft type. METHODS AND RESULTS: This report describes 4 cases of acute-onset rejection as early as 5 days following the first dose of anti-severe acute respiratory syndrome-coronavirus-2 vaccine types not yet referred for corneal allograft. Patients were individually given the Moderna messenger RNA-1273 COVID-19 vaccine (2 patients) and the AstraZeneca COVID-19 vaccine, Vaxzevria, AZD1222 (2 patients). CONCLUSIONS: Even though a direct causative effect is hard to prove, temporal proximity between anti-severe acute respiratory syndrome-coronavirus-2 vaccines of different types and consecutive reports of corneal graft rejection indicates the need for further investigation. Consistent advice must be given to corneal transplant patients regarding such risk.
PURPOSE: This study intends to add to previous reports on acute corneal graft rejection following anti-severe acute respiratory syndrome-coronavirus-2 vaccination, providing data to corroborate a possible causative relationship between anti-COVID-19 immunization and corneal graft rejection, regardless of vaccine or graft type. METHODS AND RESULTS: This report describes 4 cases of acute-onset rejection as early as 5 days following the first dose of anti-severe acute respiratory syndrome-coronavirus-2 vaccine types not yet referred for corneal allograft. Patients were individually given the Moderna messenger RNA-1273 COVID-19 vaccine (2 patients) and the AstraZeneca COVID-19 vaccine, Vaxzevria, AZD1222 (2 patients). CONCLUSIONS: Even though a direct causative effect is hard to prove, temporal proximity between anti-severe acute respiratory syndrome-coronavirus-2 vaccines of different types and consecutive reports of corneal graft rejection indicates the need for further investigation. Consistent advice must be given to corneal transplant patients regarding such risk.
Authors: Joanna Szyda; Paula Dobosz; Joanna Stojak; Mateusz Sypniewski; Tomasz Suchocki; Krzysztof Kotlarz; Magdalena Mroczek; Maria Stępień; Dawid Słomian; Sławomir Butkiewicz; Paweł Sztromwasser; Jakub Liu; Zbigniew J Król Journal: Int J Mol Sci Date: 2022-06-03 Impact factor: 6.208
Authors: Saad Alhumaid; Ali A Rabaan; Kuldeep Dhama; Shin Jie Yong; Firzan Nainu; Khalid Hajissa; Nourah Al Dossary; Khulood Khaled Alajmi; Afaf E Al Saggar; Fahad Abdullah AlHarbi; Mohammed Buhays Aswany; Abdullah Abdulaziz Alshayee; Saad Abdalaziz Alrabiah; Ahmed Mahmoud Saleh; Mohammed Ali Alqarni; Fahad Mohammed Al Gharib; Shahd Nabeel Qattan; Hassan M Almusabeh; Hussain Yousef AlGhatm; Sameer Ahmed Almoraihel; Ahmed Saeed Alzuwaid; Mohammed Ali Albaqshi; Murtadha Ahmed Al Khalaf; Yasmine Ahmed Albaqshi; Abdulsatar H Al Brahim; Mahdi Mana Al Mutared; Hassan Al-Helal; Header A Alghazal; Abbas Al Mutair Journal: Vaccines (Basel) Date: 2022-08-10