Literature DB >> 34821530

ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation.

Dongsheng Bai1, Jiaying Du1, Xiumin Bu1, Wangjia Cao1, Tifan Sun1, Jiawei Zhao1, Yue Zhao1, Na Lu1.   

Abstract

ABBREVIATIONS: ALDOA: aldolase A; AMPK: AMP-activated protein kinase; ATG: autophagy related; ATG5: autophagy related 5; ATP: adenosine triphosphate; BMDMs: bone marrow-derived macrophages; CALCOCO2: calcium binding and coiled-coil domain 2; CASP1: caspase 1; CQ: chloroquine; FOXO3: forkhead box O3; IL1B: interleukin 1 beta; LPS: lipopolysaccharide; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MT: mutant; mtDNA: mitochondrial DNA; MTORC1: mechanistic target of rapamycin kinase complex 1; mtROS: mitochondrial reactive oxygen species; NLRP3: NLR family, pyrin domain containing 3; OPTN: optineurin; PBS: phosphate-buffered saline; PRKN/Parkin: parkin RBR E3 ubiquitin protein ligase; SN: supernatant; SQSTM1/p62: sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TOMM20: translocase of outer mitochondrial membrane 20; ULK1: unc-51 like autophagy activating kinase 1; v-ATPase: vacuolar type H+-ATPase; WT: wild-type.

Entities:  

Keywords:  ALDOA; AMPK; LYG-202; NLRP3 inflammasome; mitophagy

Mesh：

Substances：

Year:  2021        PMID： 34821530      PMCID： PMC9298449          DOI： 10.1080/15548627.2021.1997051

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   13.391


  58 in total

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Authors:  Till Strowig; Jorge Henao-Mejia; Eran Elinav; Richard Flavell
Journal:  Nature       Date:  2012-01-18       Impact factor: 49.962

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4.  Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes.

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Journal:  Osteoarthritis Cartilage       Date:  2017-08-08       Impact factor: 6.576

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Authors:  Mohamed Lamkanfi; Vishva M Dixit
Journal:  Annu Rev Cell Dev Biol       Date:  2012-09-10       Impact factor: 13.827

6.  Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress.

Authors:  Yue Zhao; Qinglong Guo; Qin Zhu; Renxiang Tan; Dongsheng Bai; Xiumin Bu; Binyan Lin; Kai Zhao; Chuyue Pan; Haiyan Chen; Na Lu
Journal:  Mucosal Immunol       Date:  2019-05-31       Impact factor: 7.313

7.  A lysine to arginine substitution at position 146 of rabbit aldolase A changes the rate-determining step to Schiff base formation.

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Journal:  Protein Eng       Date:  1996-01

8.  Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Authors:  Daniel F Egan; David B Shackelford; Maria M Mihaylova; Sara Gelino; Rebecca A Kohnz; William Mair; Debbie S Vasquez; Aashish Joshi; Dana M Gwinn; Rebecca Taylor; John M Asara; James Fitzpatrick; Andrew Dillin; Benoit Viollet; Mondira Kundu; Malene Hansen; Reuben J Shaw
Journal:  Science       Date:  2010-12-23       Impact factor: 47.728

9.  The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.

Authors:  Toby A Dite; Naomi X Y Ling; John W Scott; Ashfaqul Hoque; Sandra Galic; Benjamin L Parker; Kevin R W Ngoei; Christopher G Langendorf; Matthew T O'Brien; Mondira Kundu; Benoit Viollet; Gregory R Steinberg; Kei Sakamoto; Bruce E Kemp; Jonathan S Oakhill
Journal:  Nat Commun       Date:  2017-09-18       Impact factor: 14.919

10.  PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.

Authors:  Qisheng Lin; Shu Li; Na Jiang; Xinghua Shao; Minfang Zhang; Haijiao Jin; Zhen Zhang; Jianxiao Shen; Yijun Zhou; Wenyan Zhou; Leyi Gu; Renhua Lu; Zhaohui Ni
Journal:  Redox Biol       Date:  2019-06-11       Impact factor: 11.799
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  1 in total

1.  The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.

Authors:  Chen-Song Zhang; Mengqi Li; Yu Wang; Xiaoyang Li; Yue Zong; Shating Long; Mingliang Zhang; Jin-Wei Feng; Xiaoyan Wei; Yan-Hui Liu; Baoding Zhang; Jianfeng Wu; Cixiong Zhang; Wenhua Lian; Teng Ma; Xiao Tian; Qi Qu; Yaxin Yu; Jinye Xiong; Dong-Tai Liu; Zhenhua Wu; Mingxia Zhu; Changchuan Xie; Yaying Wu; Zheni Xu; Chunyan Yang; Junjie Chen; Guohong Huang; Qingxia He; Xi Huang; Lei Zhang; Xiufeng Sun; Qingfeng Liu; Abdul Ghafoor; Fu Gui; Kaili Zheng; Wen Wang; Zhi-Chao Wang; Yong Yu; Qingliang Zhao; Shu-Yong Lin; Zhi-Xin Wang; Hai-Long Piao; Xianming Deng; Sheng-Cai Lin
Journal:  Nat Metab       Date:  2022-10-10
  1 in total

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