Literature DB >> 34817844

Successful treatment of acute-on-chronic liver failure secondary to alcoholic cirrhosis with glucocorticoids and albumin: a case report.

Jiuqin Zhou1, Si Chen2, Lin Zhang1, Yongzhen Zhai3.   

Abstract

Glucocorticoids are used as a first-line treatment for severe alcoholic hepatitis, and albumin reduces both the number of hospitalizations and mortality in patients with decompensated cirrhosis. However, for acute-on-chronic liver failure (ACLF), there is no definitive evidence that glucocorticoid therapy is beneficial. In this case report, we describe a male patient who developed into ACLF based on alcoholic cirrhosis, whose symptoms and clinical indicators continued to deteriorate after initial symptomatic treatment. The patient's condition gradually improved after low-dose glucocorticoid therapy, and long-term albumin supplementation resulted in a satisfactory outcome.
© 2021. Springer Nature Switzerland AG.

Entities:  

Keywords:  Acute-on-chronic liver failure; Albumin; Alcoholic cirrhosis; Glucocorticoids; Spontaneous bacterial peritonitis

Mesh:

Substances:

Year:  2021        PMID: 34817844      PMCID: PMC9114176          DOI: 10.1007/s40199-021-00420-w

Source DB:  PubMed          Journal:  Daru        ISSN: 1560-8115            Impact factor:   4.088


  19 in total

1.  MELDing the Lille Score to More Accurately Predict Mortality in Alcoholic Hepatitis.

Authors:  Patrick S Kamath; Terry Therneau; Vijay H Shah
Journal:  Gastroenterology       Date:  2015-06-25       Impact factor: 22.682

2.  Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis.

Authors:  Javier Fernández; Joan Clària; Alex Amorós; Ferrán Aguilar; Miriam Castro; Mireia Casulleras; Juan Acevedo; Marta Duran-Güell; Laura Nuñez; Montserrat Costa; Mireia Torres; Raquel Horrillo; Luis Ruiz-Del-Árbol; Cándido Villanueva; Verónica Prado; Mireya Arteaga; Jonel Trebicka; Paolo Angeli; Manuela Merli; Carlo Alessandria; Niels Kristian Aagaard; German Soriano; François Durand; Alexander Gerbes; Thierry Gustot; Tania M Welzel; Francesco Salerno; Rafael Bañares; Victor Vargas; Agustin Albillos; Aníbal Silva; Manuel Morales-Ruiz; Juan Carlos García-Pagán; Marco Pavesi; Rajiv Jalan; Mauro Bernardi; Richard Moreau; Antonio Páez; Vicente Arroyo
Journal:  Gastroenterology       Date:  2019-03-22       Impact factor: 22.682

3.  Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases.

Authors:  David W Crabb; Gene Y Im; Gyongyi Szabo; Jessica L Mellinger; Michael R Lucey
Journal:  Hepatology       Date:  2020-01       Impact factor: 17.425

4.  Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data.

Authors:  Philippe Mathurin; John O'Grady; Robert L Carithers; Martin Phillips; Alexandre Louvet; Charles L Mendenhall; Marie-José Ramond; Sylvie Naveau; Willis C Maddrey; Timothy R Morgan
Journal:  Gut       Date:  2010-10-12       Impact factor: 23.059

Review 5.  Grand Rounds: Alcoholic Hepatitis.

Authors:  Ashwani K Singal; Alexandre Louvet; Vijay H Shah; Patrick S Kamath
Journal:  J Hepatol       Date:  2018-06-13       Impact factor: 25.083

6.  The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids.

Authors:  Alexandre Louvet; Sylvie Naveau; Marcelle Abdelnour; Marie-José Ramond; Emmanuel Diaz; Laetitia Fartoux; Sébastien Dharancy; Frédéric Texier; Antoine Hollebecque; Lawrence Serfaty; Emmanuel Boleslawski; Pierre Deltenre; Valérie Canva; François-René Pruvot; Philippe Mathurin
Journal:  Hepatology       Date:  2007-06       Impact factor: 17.425

7.  ACG Clinical Guideline: Alcoholic Liver Disease.

Authors:  Ashwani K Singal; Ramon Bataller; Joseph Ahn; Patrick S Kamath; Vijay H Shah
Journal:  Am J Gastroenterol       Date:  2018-01-16       Impact factor: 10.864

8.  Corticosteroid improves liver function but does not curb the clinical progression of hepatitis B virus-related acute-on-chronic pre-liver failure.

Authors:  Fang Chen; Yuzhi Shi; Xueqin Liu; Lan Lei; Jian Xu
Journal:  Expert Rev Gastroenterol Hepatol       Date:  2019-11-04       Impact factor: 3.869

Review 9.  Acute-on-chronic liver failure.

Authors:  Tae Yeob Kim; Dong Joon Kim
Journal:  Clin Mol Hepatol       Date:  2013-12-28

10.  Early, short-term, low-dose glucocorticoid therapy effectively blocks progression of severe acute exacerbation of chronic hepatitis B to liver failure.

Authors:  Wu Zhe-Bin; Wang Ke; Zhi-Shuo Mo; Xu Zhen; Zheng Yu-Bao; Yan Ying; Gao Zhi-Liang
Journal:  Clin Res Hepatol Gastroenterol       Date:  2020-09-28       Impact factor: 2.947

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