Literature DB >> 34816400

Use of a Ferret Model to Test Efficacy and Immunogenicity of Live Attenuated Mycobacterium avium Subspecies paratuberculosis Vaccines.

John P Bannantine1, Tuhina Gupta2, Denise K Zinniel3, Ahmed Hikal2, Frederick D Quinn2, Raul G Barletta3.   

Abstract

Native hosts for the bacterial agent that causes Johne's disease are ruminants, which include cattle, sheep and goats among others. These large animals are often too costly to be used in testing experimental vaccines. In this chapter, we provide detailed methods to use an inexpensive and more manageable animal host, the ferret, to test efficacy and immunogenicity of live-attenuated Mycobacterium avium subspecies paratuberculosis (MAP) mutant strains prior to consideration as vaccine candidates.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Animal model; Ferrets; Johne’s disease; Mycobacterium; Paratuberculosis

Mesh：

Substances：

Year:  2022        PMID： 34816400     DOI： 10.1007/978-1-0716-1888-2_5

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

1.  Oral infection of ferrets with virulent Mycobacterium bovis or Mycobacterium avium: susceptibility, pathogenesis and immune response.

Authors:  M L Cross; R E Labes; C G Mackintosh
Journal:  J Comp Pathol       Date:  2000-07       Impact factor: 1.311

2.  Early immune markers associated with Mycobacterium avium subsp. paratuberculosis infection in a neonatal calf model.

Authors:  J R Stabel; S Robbe-Austerman
Journal:  Clin Vaccine Immunol       Date:  2011-01-12

3.  Transmission of Mycobacterium bovis from experimentally infected ferrets to non-infected ferrets (Mustela furo).

Authors:  T Qureshi; R E Labes; M Lambeth; H Montgomery; J F Griffin; C G Mackintosh
Journal:  N Z Vet J       Date:  2000-08       Impact factor: 1.628

4.  Pathogenesis of Mycobacterium avium subsp. paratuberculosis in neonatal calves after oral or intraperitoneal experimental infection.

Authors:  J R Stabel; M V Palmer; B Harris; B Plattner; J Hostetter; S Robbe-Austerman
Journal:  Vet Microbiol       Date:  2008-12-06       Impact factor: 3.293

Review 5.  Experimental animal infection models for Johne's disease, an infectious enteropathy caused by Mycobacterium avium subsp. paratuberculosis.

Authors:  Douglas J Begg; Richard J Whittington
Journal:  Vet J       Date:  2007-04-20       Impact factor: 2.688

6.  A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis.

Authors:  Lyanne McCallan; David Corbett; Peter L Andersen; Claus Aagaard; David McMurray; Claire Barry; Suzan Thompson; Samuel Strain; Jim McNair
Journal:  Vet Med Int       Date:  2011-04-12

Review 7.  Using the Ferret as an Animal Model for Investigating Influenza Antiviral Effectiveness.

Authors:  Ding Y Oh; Aeron C Hurt
Journal:  Front Microbiol       Date:  2016-02-04       Impact factor: 5.640
  7 in total

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