Literature DB >> 3481435

Decreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA.

Y Sugimoto1, I B Roninson, T Tsuruo.   

Abstract

Amplification and increased expression of the mdr1 gene associated with multidrug resistance in human tumors were found in multidrug-resistant sublines of human myelogenous leukemia K562 selected with vincristine (K562/VCR) or adriamycin (K562/ADM). In two revertant cell lines of K562/ADM, amplification of the mdr1 gene was maintained at the same level as in K562/ADM, but expression of the 4.5-kilobase mdr1 mRNA was greatly decreased, indicating that amplified genes may be inactivated at the level of transcription without a corresponding loss of amplified DNA.

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Year:  1987        PMID： 3481435      PMCID： PMC368140          DOI： 10.1128/mcb.7.12.4549-4552.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  31 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.

Authors:  R L Juliano; V Ling
Journal:  Biochim Biophys Acta       Date:  1976-11-11

3.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

4.  Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.

Authors:  S Nakajima-Iijima; H Hamada; P Reddy; T Kakunaga
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

5.  Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

Authors:  W T Beck; T J Mueller; L R Tanzer
Journal:  Cancer Res       Date:  1979-06       Impact factor: 12.701

6.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

7.  Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

Authors:  R H Peterson; M B Meyers; B A Spengler; J L Biedler
Journal:  Cancer Res       Date:  1983-01       Impact factor: 12.701

8.  The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.

Authors:  K Ueda; M M Cornwell; M M Gottesman; I Pastan; I B Roninson; V Ling; J R Riordan
Journal:  Biochem Biophys Res Commun       Date:  1986-12-30       Impact factor: 3.575

9.  Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.

Authors:  N Kartner; J R Riordan; V Ling
Journal:  Science       Date:  1983-09-23       Impact factor: 47.728

10.  Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gels.

Authors:  I B Roninson
Journal:  Nucleic Acids Res       Date:  1983-08-25       Impact factor: 16.971
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  15 in total

1.  Stability and expression of amplified EPSPS genes in glyphosate resistant tobacco cells and plantlets.

Authors:  J D Jones; P B Goldsbrough; S C Weller
Journal:  Plant Cell Rep       Date:  1996-02       Impact factor: 4.570

2.  ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes.

Authors:  Matteo Cassandri; Alessio Butera; Ivano Amelio; Anna Maria Lena; Manuela Montanaro; Alessandro Mauriello; Lucia Anemona; Eleonora Candi; Richard A Knight; Massimiliano Agostini; Gerry Melino
Journal:  Oncogene       Date:  2020-04-20       Impact factor: 9.867

Review 3.  Defective drug uptake contributing to multidrug resistance in hepatoma cells can be evaluated in vitro.

Authors:  H P Buscher
Journal:  Klin Wochenschr       Date:  1990-05-04

4.  Organization of the amplified type I interferon gene cluster and associated chromosome regions in the interphase nucleus of human osteosarcoma cells.

Authors:  Michael J Zeitz; Narasimharao V Marella; Kishore S Malyavantham; Sandra Goetze; Juergen Bode; Ivan Raska; Ronald Berezney
Journal:  Chromosome Res       Date:  2009-03-13       Impact factor: 5.239

Review 5.  Molecular cytogenetics of multiple drug resistance.

Authors:  P V Schoenlein
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

Review 6.  Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro.

Authors:  B T Hill
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

Review 7.  Anthracycline antibiotics in cancer therapy. Focus on drug resistance.

Authors:  D J Booser; G N Hortobagyi
Journal:  Drugs       Date:  1994-02       Impact factor: 9.546

8.  P-glycoprotein gene amplification and expression in multidrug-resistant murine P388 and B16 cell lines.

Authors:  G Capranico; P De Isabella; C Castelli; R Supino; G Parmiani; F Zunino
Journal:  Br J Cancer       Date:  1989-05       Impact factor: 7.640

9.  P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer.

Authors:  Ryohei Katayama; Takuya Sakashita; Noriko Yanagitani; Hironori Ninomiya; Atsushi Horiike; Luc Friboulet; Justin F Gainor; Noriko Motoi; Akito Dobashi; Seiji Sakata; Yuichi Tambo; Satoru Kitazono; Shigeo Sato; Sumie Koike; A John Iafrate; Mari Mino-Kenudson; Yuichi Ishikawa; Alice T Shaw; Jeffrey A Engelman; Kengo Takeuchi; Makoto Nishio; Naoya Fujita
Journal:  EBioMedicine       Date:  2015-12-12       Impact factor: 8.143

Review 10.  The well-accepted notion that gene amplification contributes to increased expression still remains, after all these years, a reasonable but unproven assumption.

Authors:  Yuping Jia; Lichan Chen; Qingwen Jia; Xixi Dou; Ningzhi Xu; Dezhong Joshua Liao
Journal:  J Carcinog       Date:  2016-05-20
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