Vanessa Kelly da Silva Lage1, Fabiana Angélica de Paula1, Jousielle Márcia Dos Santos1, Henrique Silveira Costa2, Guilherme Pinto da Silva3, Liliana Pereira Lima1, Joyce Noelly Vítor Santos4, Hellen Cristina de Almeida1, Pedro Henrique Scheidt Figueiredo2, Mario Bernardo-Filho5, Redha Taiar6, Antônio Lúcio Teixeira7, Ana Cristina Rodrigues Lacerda8, Vanessa Amaral Mendonça9. 1. Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Laboratório de Inflamação e Metabolismo - LIM, CIPq Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil. 2. Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil. 3. Laboratório de Inflamação e Metabolismo - LIM, CIPq Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil. 4. Laboratório de Inflamação e Metabolismo - LIM, CIPq Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil. 5. Laboratório de Vibrações Mecânicas e Práticas Integrativas, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes and Policlínica Américo Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. 6. MATIM, Moulin de la Housse, Université de Reims Champagne Ardenne, Reims Cedex 2 51687, France. 7. Instituto de Ensino e Pesquisa Santa Casa BH, Belo Horizonte, Brazil; McGovern Medical School, UT Health Houston, Houston, USA. 8. Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Laboratório de Inflamação e Metabolismo - LIM, CIPq Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil. 9. Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Laboratório de Inflamação e Metabolismo - LIM, CIPq Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil. Electronic address: vaafisio@hotmail.com.
Abstract
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) often present with sarcopenia, a condition marked by the loss in quality and quantity of muscle mass that can affect the strength of respiratory muscles. COPD and sarcopenia are also independently associated with oxidative stress. This study aimed to investigate whether oxidative stress biomarkers and respiratory muscle strength are associated with sarcopenia in COPD patients. METHODS: In a cross-sectional study, 86 elderly subjects, including subjects with and without COPD were assessed for body composition, maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) and oxidative stress parameters [substances reactive to thiobarbituric acid (TBARS), ferric reducing ability of plasma (FRAP), superoxide dismutase (SOD), and catalase (CAT)]. RESULTS: The sample was mainly composed by males (72.1%) and eutrophic subjects. COPD-related sarcopenia was evidenced in 51.1% (22/43) of subjects with COPD. The highest TBARS and CAT, and lower MIP and MEP were associated with a high probability of having COPD-related sarcopenia. In the multivariate analysis, TBARS (OR: 4.89, 95% CI 1.52 to 15.54, p = 0.006), CAT (OR: 1.22, 95% CI 1.03 to 1.45, p = 0.020) and MEP (OR: 0.97, 95% CI 0.95 to 0.99, p = 0.020) were independent determinants of COPD-related sarcopenia. CONCLUSION: The increase in oxidative stress-related factors and the reduction of respiratory muscle strength are associated with COPD-related sarcopenia.
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) often present with sarcopenia, a condition marked by the loss in quality and quantity of muscle mass that can affect the strength of respiratory muscles. COPD and sarcopenia are also independently associated with oxidative stress. This study aimed to investigate whether oxidative stress biomarkers and respiratory muscle strength are associated with sarcopenia in COPD patients. METHODS: In a cross-sectional study, 86 elderly subjects, including subjects with and without COPD were assessed for body composition, maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) and oxidative stress parameters [substances reactive to thiobarbituric acid (TBARS), ferric reducing ability of plasma (FRAP), superoxide dismutase (SOD), and catalase (CAT)]. RESULTS: The sample was mainly composed by males (72.1%) and eutrophic subjects. COPD-related sarcopenia was evidenced in 51.1% (22/43) of subjects with COPD. The highest TBARS and CAT, and lower MIP and MEP were associated with a high probability of having COPD-related sarcopenia. In the multivariate analysis, TBARS (OR: 4.89, 95% CI 1.52 to 15.54, p = 0.006), CAT (OR: 1.22, 95% CI 1.03 to 1.45, p = 0.020) and MEP (OR: 0.97, 95% CI 0.95 to 0.99, p = 0.020) were independent determinants of COPD-related sarcopenia. CONCLUSION: The increase in oxidative stress-related factors and the reduction of respiratory muscle strength are associated with COPD-related sarcopenia.
Authors: Renato Fleury Cardoso; Ana Cristina Rodrigues Lacerda; Vanessa Pereira Lima; Lucas Fróis Fernandes de Oliveira; Sofia Fróis Fernandes de Oliveira; Rafaela Paula Araújo; Cecylia Leiber Fernandes E Castro; Flávia Pereira da Silva; Lizânia Vieira de Paiva; Lia Dietrich; Pedro Henrique Scheidt Figueiredo; Henrique Silveira Costa; Mario Bernardo-Filho; Danúbia da Cunha de Sá-Caputo; Vanessa Amaral Mendonça; Redha Taiar Journal: J Clin Med Date: 2022-05-28 Impact factor: 4.964
Authors: Diksha Bains; Aksh Chahal; Mohammad Abu Shaphe; Faizan Z Kashoo; Taimul Ali; Ahmad H Alghadir; Masood Khan Journal: Biomed Res Int Date: 2022-07-30 Impact factor: 3.246