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Literature DB >> 348126

Gonadotrophin release in untreated congenital virilising adrenal hyperplasia.

A Pertzelan, Z Laron, M Adler-Bier, R Prager-Lewin, H Kaufman.

Abstract

A 9.9-year-old boy and a 9.8-year-old girl with virilising congenital adrenal hyperplasia were subjected to an IV LH-RH (luteinising hormone-releasing hormone) test (so microgram/m2 before initition of therapy with corticosteroids. The pattern of response of LH and follicle-stimulating hormone to LH-RH was found to correspond to the stage of their precocious sexual development and advanced bone age, but not to their chronological age. This finding has implications with regard to the mechanism controlling gonadotrophin secretion at puberty.

Entities: Disease Gene Species

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Year: 1978 PMID： 348126 PMCID： PMC1544865 DOI： 10.1136/adc.53.4.305

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

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References

8 in total

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Authors: J Kirkland; R Kirkland; L Librik; G Clayton
Journal: J Pediatr Date: 1974-03 Impact factor: 4.406

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Journal: J Clin Endocrinol Metab Date: 1973-05 Impact factor: 5.958

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Authors: V C Stevens; J W Goldzieher
Journal: Pediatrics Date: 1968-02 Impact factor: 7.124

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Authors: Z Laron; M Karp; L Dolberg
Journal: Acta Paediatr Scand Date: 1970-05

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Authors: E O Reiter; M M Grumbach; S L Kaplan; F A Conte
Journal: J Clin Endocrinol Metab Date: 1975-02 Impact factor: 5.958

Gonadotrophin release in untreated congenital virilising adrenal hyperplasia.

1. Serum gonadotropin levels in female adolescents with congenital adrenal hyperplasia.

2. Precocious puberty following treatment in a 6-year-old male with congenital adrenal hyperplasia: studies of serum luteinizing hormone (LH), serum follicle stimulating hormone (FSH) and plasma testosterone.

3. Urinary excretion of gonadotropins in congenital adrenal hyperplasia.

4. Juvenile hypothyroidism with testicular enlargement.

5. The response of pituitary gonadotropes to synthetic LRF in children with glucocorticoid-treated congenital adrenal hyperplasia: lack of effect of intrauterine and neonatal androgen excess.

6. Response of plasma LH and FSH to synthetic LH-RH in children at various pubertal stages.

7. Gonadotropin output and response to LRH administration in congenital virilizing adrenal hyperplasia.

8. Gonadotropin output in congenital adrenal hyperplasia before and after adrenal suppression.