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Literature DB >> 3481242

Naltrexone decreases self-injurious behavior.

B H Herman¹, M K Hammock, A Arthur-Smith, J Egan, I Chatoor, A Werner, N Zelnik.

Abstract

The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.

Entities: Chemical Disease

Mesh：

Substances：
Naltrexone

Year: 1987 PMID： 3481242 DOI： 10.1002/ana.410220419

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

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Cited

11 in total

1. Brief report: a double-blind study of naltrexone in infantile autism.

Authors: M Leboyer; M P Bouvard; J M Launay; F Tabuteau; D Waller; M Dugas; B Kerdelhue; P Lensing; J Panksepp
Journal: J Autism Dev Disord Date: 1992-06

2. Initial aggravation of self-injurious behavior in autistic patients receiving naltrexone treatment.

Authors: R Knabe; P Schulz; J Richard
Journal: J Autism Dev Disord Date: 1990-12

3. Brief report: plasma beta-endorphin and cortisol levels in autistic patients.

Authors: C A Sandman; J L Barron; A Chicz-DeMet; E M DeMet
Journal: J Autism Dev Disord Date: 1991-03

4. Brief report: a synopsis of an open-trial of naltrexone treatment of autism with four children.

Authors: J Panksepp; P Lensing
Journal: J Autism Dev Disord Date: 1991-06

Review 5. Self-injurious behaviour in autistic children: a neuro-developmental theory of social and environmental isolation.

Authors: Darragh P Devine
Journal: Psychopharmacology (Berl) Date: 2013-09-21 Impact factor: 4.530

Naltrexone decreases self-injurious behavior.

1. Brief report: a double-blind study of naltrexone in infantile autism.

2. Initial aggravation of self-injurious behavior in autistic patients receiving naltrexone treatment.

3. Brief report: plasma beta-endorphin and cortisol levels in autistic patients.

4. Brief report: a synopsis of an open-trial of naltrexone treatment of autism with four children.

Review 5. Self-injurious behaviour in autistic children: a neuro-developmental theory of social and environmental isolation.

Review 6. Self-injurious behavior in neurodevelopmental disorders: relevance of nociceptive and immune mechanisms.

Review 7. Opiate antagonists in children and adolescents.

8. Self-injurious behavior and Prader-Willi syndrome: behavioral forms and body locations.

9. A case report of naltrexone treatment of self-injury and social withdrawal in autism.

10. Naltrexone treatment reverses astrocyte atrophy and immune dysfunction in self-harming macaques.