Judit Sebők1, Zsófia Édel1, Szilárd Váncsa2,3, Nelli Farkas2,4, Szabolcs Kiss5, Bálint Erőss2,3, Zsolt Török6,7, Gábor Balogh6,7, Zsolt Balogi8, Rita Nagy2,3,9, Philip L Hooper10, Paige C Geiger11, István Wittmann1, László Vigh6,7, Fanni Dembrovszky2,3, Péter Hegyi2,3,12. 1. 2nd Department of Medicine and Nephrology-Diabetes Center, Medical School, University of Pécs, Pécs, Hungary. 2. Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary. 3. Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. 4. Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary. 5. Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary. 6. LipidArt Ltd., Szeged, Hungary. 7. Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary. 8. Heim Pál National Pediatric Institute, Budapest, Hungary. 9. Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver, Aurora, CO, USA. 10. Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA. 11. Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, Hungary. 12. Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Abstract
AIMS: Type-2 diabetes mellitus (T2DM) is a common health condition which prevalence increases with age. Besides lifestyle modifications, passive heating could be a promising intervention to improve glycemic control. This study aimed to assess the efficacy of passive heat therapy on glycemic and cardiovascular parameters, and body weight among patients with T2DM. METHODS: A systematic review and meta-analysis were reported according to PRISMA Statement. We conducted a systematic search in three databases (MEDLINE, Embase, CENTRAL) from inception to 19 August 2021. We included interventional studies reporting on T2DM patients treated with heat therapy. The main outcomes were the changes in pre-and post-treatment cardiometabolic parameters (fasting plasma glucose, glycated plasma hemoglobin, and triglyceride). For these continuous variables, weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated. Study protocol number: CRD42020221500. RESULTS: Five studies were included in the qualitative and quantitative synthesis, respectively. The results showed a not significant difference in the hemoglobin A1c [WMD -0.549%, 95% CI (-1.262, 0.164), p = 0.131], fasting glucose [WMD -0.290 mmol/l, 95% CI (-0.903, 0.324), p = 0.355]. Triglyceride [WMD 0.035 mmol/l, 95% CI (-0.130, 0.200), p = 0.677] levels were comparable regarding the pre-, and post intervention values. CONCLUSION: Passive heating can be beneficial for patients with T2DM since the slight improvement in certain cardiometabolic parameters support that. However, further randomized controlled trials with longer intervention and follow-up periods are needed to confirm the beneficial effect of passive heat therapy.
AIMS: Type-2 diabetes mellitus (T2DM) is a common health condition which prevalence increases with age. Besides lifestyle modifications, passive heating could be a promising intervention to improve glycemic control. This study aimed to assess the efficacy of passive heat therapy on glycemic and cardiovascular parameters, and body weight among patients with T2DM. METHODS: A systematic review and meta-analysis were reported according to PRISMA Statement. We conducted a systematic search in three databases (MEDLINE, Embase, CENTRAL) from inception to 19 August 2021. We included interventional studies reporting on T2DM patients treated with heat therapy. The main outcomes were the changes in pre-and post-treatment cardiometabolic parameters (fasting plasma glucose, glycated plasma hemoglobin, and triglyceride). For these continuous variables, weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated. Study protocol number: CRD42020221500. RESULTS: Five studies were included in the qualitative and quantitative synthesis, respectively. The results showed a not significant difference in the hemoglobin A1c [WMD -0.549%, 95% CI (-1.262, 0.164), p = 0.131], fasting glucose [WMD -0.290 mmol/l, 95% CI (-0.903, 0.324), p = 0.355]. Triglyceride [WMD 0.035 mmol/l, 95% CI (-0.130, 0.200), p = 0.677] levels were comparable regarding the pre-, and post intervention values. CONCLUSION: Passive heating can be beneficial for patients with T2DM since the slight improvement in certain cardiometabolic parameters support that. However, further randomized controlled trials with longer intervention and follow-up periods are needed to confirm the beneficial effect of passive heat therapy.
Authors: Szilárd Váncsa; László Vigh; Péter Hegyi; Judit Sebők; Zsófia Édel; Fanni Dembrovszky; Nelli Farkas; Zsolt Török; Gábor Balogh; Mária Péter; Ildiko Papp; Zsolt Balogi; Nóra Nusser; Iván Péter; Philip Hooper; Paige Geiger; Bálint Erőss; István Wittmann Journal: BMJ Open Date: 2022-07-12 Impact factor: 3.006
Authors: Erik D Marchant; Jamie P Kaluhiokalani; Taysom E Wallace; Mohadeseh Ahmadi; Abigail Dorff; Jessica J Linde; Olivia K Leach; Robert D Hyldahl; Jayson R Gifford; Chad R Hancock Journal: Int J Mol Sci Date: 2022-07-31 Impact factor: 6.208