Factors that Hinder 24-Hour Discharge After Laparoscopic Roux-en-Y Gastric Bypass: a Retrospective Analysis at a Low-Volume Center.

PURPOSE: This study aimed to identify factors that hinder 24-h patient discharge after laparoscopic Roux-en-Y gastric bypass (LRYGB) in a low-volume practice.
MATERIAL AND METHODS: Consecutive patients who fulfilled regional criteria and underwent primary LRYGB from 2018 to 2020 were retrospectively analyzed. Patients were discharged on the morning of the first postoperative day (POD1) after meeting the predefined criteria. The assessed outcome measures (POD1 vital signs, laboratory findings, pain scores and nausea/vomiting) and 30-day postoperative complications were compared between the early (stay ≤ 24 h) and delayed (>24 h) groups.
RESULTS: For 107 patients who fulfilled the inclusion criteria, 48 (44.9%) were discharged within 24 h. There were no differences in the baseline demographics, except that the early group was more likely to have a previous abdominal operation (35.4% vs. 16.9%). Both groups had similar operation durations (89 min vs. 92 min), but the early group had a markedly shortened length of stay (23 (24-22) h vs. 27 (47-26) h). The POD1 parameters were the same between the groups, except that the delay group had a significantly higher visual analog scale score, with fewer patient scores of 0. Patients who were younger and female were more likely to need additional IV analgesics. No POD1 antiemesis was required throughout the study. There was no increase in the 30-day complications.
CONCLUSION: Patient discharge at 24 h post-LRYGB is feasible and safe in a low-volume practice. A more comprehensive pain relief strategy may be required before generalizing this approach.

Introduction

While the world battles the COVID-19 pandemic, obesity continues to have a profound impact on public health. However, many nonemergency procedures have been postponed during the peak of the COVID-19 pandemic to accommodate the resources and capacity requirements [1]. Arguably, bariatric and metabolic surgery should be performed for patients in need before the upcoming second pandemic wave because it has been increasingly utilized and widely accepted to be the only effective treatment for obesity and its related diseases [2]. Moreover, cumulative evidence has shown that obese populations have a higher risk of SARS-CoV-2 infection and complications [3] and delayed obesity treatment during the COVID-19 pandemic worsens the pre-existing comorbidities of obesity [4]. Therefore, it is vital to understand how to resume bariatric surgeries while using limited resources, reducing the risk for in-hospital infection, and maintaining the safety of the surgery.

Since their inception in 1997 [5], enhanced recovery after surgery (ERAS) protocols have successfully been shown to be a valuable modality to attenuate perioperative stress and achieve faster convalescence for various surgical disciplines [6]. With demonstrated benefits, including a shortened length of stay (LOS) and reduced overall cost [7], these protocols can be a useful and timely tool in such a situation. As evidence continues to emerge, studies have shown that it is feasible for selected patients to be discharged after 23 h on an outpatient basis after laparoscopic Roux-en-Y gastric bypass (LRYGB) [8-10]. However, these discharge plans after LRYGB usually occur in specialized high-volume centers and in experienced hands. In fact, looking at the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) data registry, merely 0.9% of all LRYGBs were discharged within 24 h [11]. Some small retrospective studies have reported that a 1-day LOS can be accomplished for 78.1–94.8% of patients [12]. Nevertheless, these studies either lacked a control group or did not take clinically relevant factors into consideration. While low-volume bariatric units are often less resourceful and perform no negligible bariatric procedures [13], there is still not a sufficient amount of data to support the early release of patients in these low-volume centers. With approximately 50 bariatric procedures performed yearly, surprisingly, we found that many patients met the discharge criteria earlier than expected. After full implementation of the ERAS protocols from 2017 and a year of adaptation, we routinely discharged all patients who underwent primary procedures the morning after the operation if not contraindicated. Unlike most studies focused on 30-day outcomes and the LOS [7, 11, 14], the objective of this study was to clarify the factors that hinder 24-h patient discharge after primary LRYGB by analyzing readily accessible clinical variables and to study safety and results at the same time.

Material and Methods

A retrospective analysis was performed from a prospectively maintained database of patients who underwent bariatric surgeries from 2018 to 2020 by a single surgeon at a university affiliated hospital. Local institutional review board approval was obtained for this study, and informed consent was waived because this was a retrospective study. All procedures performed in this study were in accordance with the ethical standards in the 1964 Declaration of Helsinki and its later amendments.

Consecutive patients who met the regional criteria [15] and who underwent primary LRYGB were enrolled. Exclusion criteria included patients with BMI>50 kg/m2 who underwent procedures other than primary LRYGB. Preoperative work-up included blood tests, chest radiographs, electrocardiograms, and upper gastrointestinal endoscopy. A standard four-port LRYGB was completed in all patients with techniques including the construction of a 30-mL vertical pouch and 100-cm alimentary (antecolic, antegastric) and biliopancreatic limbs, the completion of linear stapling anastomoses and the closure of mesenteric defects.

As shown in Table 1, our ERAS protocol consisted of preadmission education to facilitate patient readiness for discharge and to motivate early discharge. The nasogastric tube, abdominal drain, or urinary catheters are exempted. Apart from standard anesthesia, our regimen comprised the monitoring of optimal muscle tension during surgery, the depth of anesthesia, the attention to the pre-emptive antiemesis protocol, and the use of a multimodal analgesic regimen based upon reported evidence at the time [16]. Patients were encouraged to proceed with early ambulation with no thromboprophylaxis postoperatively, and a liquid diet commenced on the first postoperative day (POD1). A goal to achieve at least 1500-ml total fluid per day was given, which in turn represents approximately 100-ml/hour, considering approximately 16 h of daytime activity. The postoperative diet regimen consisted of four stages of advancement, with a clear liquid diet serving as the first stage and then slowly advancing after discharge until accustomed to a pureed diet across a 16-day time frame. Discharge was prepared in advance on the day of surgery on a regular basis and granted on the morning of the POD1 based upon reach of diet milestone and if the patient had no fever and had a stable hemodynamic status with tolerable pain and if the laboratory results were within the acceptable range. As the ideal of this research is to conduct such practice under a low-volume practice, rotation staff is not often available. The attending physician personally confirms the suitability of early release and collaborates to handle discharge. For any patients who were subjectively unwell or had concerning characteristics, we initiated a timely work-up. For these patients, a same-day discharge was still allowed after a negative secondary survey and with improved clinical status. Patients were stratified into early (≤ 24 hours) or delayed (> 24 hours) groups based on the postoperative LOS, which was measured in hours and was defined as the time from the end of the procedure to the exact time the patient left the hospital. Demographics assessed included the estimated glomerular filtration rate (eGFR), stage of chronic kidney disease (CKD), and baseline oxygen saturation (O2) as surrogates of major organ function and American Society of Anesthesiologists (ASA) physical status classification. The primary outcomes evaluated included POD1 vital signs and laboratory survey results. Having been demonstrated to be a reliable and valid measure for acute pain and limited by its retrospective design, the patient-reported intensity of abdominal pain is rated according to the visual analog scale (VAS) [17] with increments of severity ranging from 0 to 10, and the use of analgesic or anti-emetic medications is collected. The 30-day complications served as the secondary outcome measures. Patients were followed postoperatively at 1 week and 1, 3, 6, and 12 months postoperatively and then annually thereafter.

Table 1.

ERAS protocol

Phase of care	ERAS goal (content)	Route (dosage)
Preadmission	Instructions to provide clear expectations and goals
Intra-operation	No nasogastric tube
	No Foley catheter
	No abdominal drain
Anesthesia
Deep neuromuscular blockage	Optimal muscle tension (train of four monitor)	IV Sugammadex (2–4 mg/kg)
Depth of anesthesia	Bispectral index
Pre-emptive anti-emesis protocol	Goal directed fluid replacement (total < 1.5 L)
Induction	Dexamethasone	IV 10 mg
Before the end of surgery	Droperidol	IV 0.625–2.5 mg
Postoperative	Metoclopramide	IV 10 mg q8 h
	Granisetron	IV 3 mg and QD on demand
Multimodal analgesic regimen	Total elimination of opioid use
Preoperative	Clonidine	po 75mcg
	Pregabalin	po 75 mg
	Acetaminophen	IV 1000 mg
Induction	Propofol	IV 1% 1–2.5 mg/kg
	Fentanyl	IV 1–2 mcg/kg
Intraoperative	Transverses abdominis plane block	Bupivacaine, 0.5%, total 40 ml
	Port site local injection
	Intraperitoneal spray	One-time spray after pneumoperitoneum
At the end of procedure	Fentanyl	IV 50 mcg on demand
	Ketorolac	IV 30 gm on demand
Postoperative	Parecoxib	IV 40 gm and QD on demand
	Acetaminophen	IV 1000 mg q6 h on demand
Patient care
Postoperative	Sip water, rigorous early ambulation
POD1	Clear liquids, routine lab survey, handout discharge instructions, oral acetaminophen

ERAS enhanced recovery after surgery, IV intravenous, POD1 postoperative day one

Statistical analysis was performed using R 4.1.0 software (R Foundation for Statistical Computing, Vienna, Austria). The normality of the data was assessed by the Shapiro–Wilk test. Continuous variables were expressed as the means and standard deviation or medians and the interquartile range when appropriate and were compared by Student’s t test or the Mann-Whitney U-test. Categorical variables were expressed as counts or percentages and analyzed with the chi-squared test or Fisher’s direct exact test. Statistical tests were two-sided, and a value of p < 0.05 was considered statistically significant.

Results

From 2018 to 2020, a total of 168 patients underwent bariatric surgery at our hospital. Among 107 who fulfilled the inclusion criteria, 48 (44.9%) were discharged within 24 h, and the other 59 (55.1%) stayed more than 24 h.

The demographic features and clinical characteristics are outlined in Table 2. No significant differences were found between the groups with respect to age, female sex, body mass index (BMI), or incidence of comorbidities, except that the early group had significantly more prior abdominal operations (17 (35.4%) vs. 10 (16.9%); p=0.049), which were mostly gynecological procedures due to exclusively benign lesions. In our study, no patients required changes in their treatment plan throughout the study. There were also no differences in the eGFR, stage of CKD, O2 saturation, or ASA between the groups.

Table 2.

Clinical characteristics of the patients

Variables	Early group(N = 48)	Delayed group(N = 59)	P value
Age (years), median (IQR)	38 (42.3–31.0)	36.0 (42.5–30.0)	0.660
Female, n (%)	31 (64.6)	36 (61.0)	0.858
BMI (kg/m2), median (IQR)	36.6 (38.8–34.9)	37.3 (40.0–34.9)	0.535
Prior abdominal operation, n (%)	17 (35.4)	10 (16.9)	0.049*
Visceral	4	2	0.820
Gynecological	11	8
Others	2
Comorbidity, n (%)
Diabetes mellitus	14 (29.2)	18 (30.5)	1.00
Insulin	1	4	0.354
OHA	13	14
Hypertension	18 (37.5)	24 (40.7)	0.892
Dyslipidemia	34 (70.8)	35 (59.3)	0.300
GERD	22 (45.8)	30 (50.8)	0.747
eGFR (mL/min/1.73m2), mean (SD)	121.0 (27.0)	113.9 (23.5)	0.155
CKD stage 1	19	26	0.754
CKD stage 2	6	9
CKD stage 3	0	1
O2 sat (%), median (IQR)	96.0 (98.0–96.0)	97.0 (98.5–96.0)	0.394
ASA, n (%)
II	39 (81.3)	47 (79.7)	1.00
III	9 (18.7)	12 (20.3)

ASA American Society of Anesthesiologists Classification, BMI body mass index, CKD chronic kidney disease, eGFR estimated glomerular filtration rate, GERD gastroesophageal reflux disease, OHA oral hypoglycemic agent, O sat oxygen saturation

*P < 0.05

The surgical results and POD1 parameters are depicted in Table 3. There was an equivalent median operation time (89 min vs. 92 min; p=0.636) between the groups and the LOS was markedly shortened in the early group (23 (24–22) h vs. 27 (47–26) h; p < 0.001). There was no difference in vital signs or laboratory data, including white blood cell (WBC) count, percentages of neutrophils, C-reactive protein (CRP), hemoglobin (Hb) decline, and Hb value at baseline or on POD1 between the groups. The early group had a significantly lower POD1 pain scale (1 (1–0) vs. 1 (2–1); p =0.001) and had more patients with a pain scale of 0 (31.3% vs. 8.5%; p =0.005). As both pain relievers (e.g., parecoxib and acetaminophen) were given on demand after surgery, there was a trend in the early group for a less frequent request for these analgesics (2.1% vs. 11.9%; p =0.071) on the morning of POD1. Apart from one patient in each group who required a single dose of morphine, each group had another patient; one in the early group received ketorolac, and the other in the delay group received tramadol to control breakthrough pain at the night of the operation. None of the other patients received any other pain relievers outside of our protocol or had a requirement for antiemetic medications. The incidence of 30-day ER visits, readmissions, and overall complications (1 (2.1%) vs. 3 (5.1%); p=0.626) were the same between the groups. Complications included one patient with hematochezia in the early group who required readmission via the ER. In the delay group, two patients were readmitted via the ER for self-limiting hematemesis. A third patient experienced transient melena at POD7. There was no anastomotic leakage, open conversion or mortality reported in any of the patients. At the 1-year follow-up, the percentage of excessive weight loss and the percentage of total weight loss in either group were 77.7% and 27.9% vs. 85.6% and 31.8%, respectively.

Table 3.

Surgical perspectives, outcomes and POD1 parameters

Variables	Early group	Delayed group	P value
Operative duration (min), median (IQR)	89.0 (97.5–82.8)	92.0 (103.0–81.5)	0.636
LOS (hours), median (IQR)	23 (24–22)	27 (47–26)	< 0.001*
POD1 parameters
BT (°C), median (IQR)	36.6 (36.8–36.4)	36.6 (36.8–36.4)	0.879
PR (bpm), mean (SD)	73.3 (11.1)	71.5 (11.5)	0.406
RR (BPM), median (IQR)	16 (18–16)	17 (18–16)	0.724
SBP (mmHg), mean (SD)	124.8 (14.6)	124.8 (14.9)	0.993
WBC (103/ul), median (IQR)	12.62 (14.15–10.73)	12.54 (14.19–10.84)	0.873
> 14,000, n (%)	14 (29.2%)	17 (28.8%)	1.00
Neutrophil %, median (IQR)	76.6 (79.9–72.9)	77.5 (79.3–73.3)	0.843
> 85%, n (%)	3 (6.3%)	1 (1.7%)	0.323
Hb baseline (g/dl), median (IQR)	14.5 (15.6–13.9)	14.5 (15.8–13.9)	0.633
Hb POD1, median (IQR)	13.0 (13.9–12.4)	13.0 (13.9–12.3)	0.702
Hb decline >2, n (%)	9 (18.8)	13 (22.0)	0.859
CRP (mg/dl), median (IQR)	1.5 (2.2–1.3)	1.5 (2.4–1.1)	0.746
CRP >6, n (%)	3 (6.3)	2 (3.4)	0.655
VAS, median (IQR)	1 (1–0)	1 (2–1)	0.001*
VAS 0, n (%)	15 (31.3)	5 (8.5)	0.005*
Analgesics requirement, n (%)	1 (2.1)	7 (11.9)	0.071
Anti-emesis, n (%)	0	0	1.00
30-day ER visits, n (%)	1(2.1)	4 (6.8)	0.376
30-day readmission, n (%)	1(2.1)	2 (3.4)	1.00
30-day complications, n (%)	1(2.1)	3 (5.1)	0.626

BPM breaths per minute, BT body temperature, CRP C-reactive protein, ER emergency room, Hb hemoglobin, LOS length of stay, POD1 postoperative day one, PR pulse rate, RR respiratory rate, SBP systolic blood pressure, VAS Visual Analog Scale, WBC white blood cell

*P < 0.05

Discussion

With a shortened hospital stay and no increase in complications, our data support the feasibility and safety of 24-h discharge after LRYGB in a low-volume setting. Postoperative abdominal pain appears to be the only causative factor in our study that affects early discharge. In this regard, a collaborative multidisciplinary approach for more satisfactory pain relief should help more suitable patients be discharged early.

LRYGB is considered the gold-standard bariatric procedure and is performed only second to sleeve gastrectomy. LRYGB generally has an LOS of 2 days [8] and has a higher risk profile than sleeve gastrectomy [18]. Systemic reviews suggest that it is feasible to discharge patients within 23 h after primary LRYGB [7, 12]. However, controversies continue regarding its drawbacks. For instance, Morton et al. [8] discovered that a postoperative LOS of ≤1 day was associated with a significantly increased risk of 30-day mortality. Inaba et al. [14] also found that there was a significantly higher risk-adjusted overall morbidity and readmission for same-day discharge using the MBSAQIP database. In contrast, other studies have shown no increase in 30-day morbidities under this approach [11, 19]. Importantly, the nature of abdominal symptoms can be vague and insidious because of obesity. Since independent vital signs such as a heart rate of >120/min, respiratory distress (respiratory rate >22/min) [20] or a combination of these are frequently referred to as essential indicators in identifying complications early, we paid extra attention to these parameters and conducted this approach cautiously. Corresponding to the overall low complications, none of our patients experienced fever, dyspnea, tachycardia, or unstable blood pressure on POD1; additionally, there was no difference in these factors between the groups. Furthermore, despite the major disadvantage of the lack of specificity [21] and the optimal detection time and standard value not being conclusive [22], we routinely performed blood sampling on POD1 and interpreted the results based on strict reported standards, including a WBC count >14 ×103/μL [21], percentage of neutrophils >85%, CRP > 6 mg/dl [23] and serial Hb decline > 2 g/dL [23]. These factors were used as complementary tools to help screen patients who could have complications. Further analysis revealed that none of these factors reached statistical significance or correlated directly with the development of complications. However, the current study may be underpowered to detect significance given the low patient number and the low incidence of complications in this study. In referring to previous large studies with reported readmission rates ranging between 1.7 and 5.6%, reoperation between 1.02 and 2.49%, overall complication rates between 1.9 and 3.76%, and mortality rates up to 0.94% [9–11, 14, 19], our results fall within these ranges and therefore meet the safety standards.

Importantly, as prerequisites for successful and safe early patient discharge, there are currently no established patient selection or exclusion criteria. While multivariate analysis proposed that surgeon experience < 50 cases, patient age > 56, BMI > 60, patient weight > 400 lbs, and patient comorbidities > 4 were unfavorable factors for early discharge [10], there was no difference in the patients’ demographics that reflected these conditions between the groups. In other words, we did not select lower-risk patients to achieve the goal of early discharge. Notably, the patients in our study had a lower median BMI in both groups (36.6 and 37.3 kg/m2, respectively) than previous reports that described patient BMIs ranging from 41.2 to 49.3 kg/m2 [7]. Part because a body mass index (BMI) >50 kg/m2 was not considered suitable for LRYGB in our practice because gastric bypass is generally less effective in these patients [24], and these patients generally have a higher rate of complications than patients with a lower BMI [25]. Since only 19% of patients in the early group (BMI range, 32.8-45.9 kg/m2) and 25% of patients in the delay group (BMI range, 32.5-48.1 kg/m2) have BMI >40 kg/m2 and because most of our patients belonged to ASA class II, our patient groups appear to have had a lower risk, and such practices are in line with the aforementioned recommendations [7, 10]. Conversely, after taking into account the reported high discharge rate, for instance, McCarty et al. [10] proposed that 84% of 2000 LRYGB patients can be successfully discharged within 23 h, and Hahl et al. [26] reported a high POD1 discharge rate of up to 83% in a 318 patient series; our study had inferior results since only 44.9% of our patients were discharged within 24 h. Part of the reason for our data may be because we reported the LOS by the hour, and we are less experienced. Intergroup analysis revealed that postoperative pain serves as the only factor that hinders early discharge despite both groups having no underlying differences in the patient demographics, using the same multimodal analgesics regimen, having a generally low pain scale, and specifically, only 11.9% of patients in the delayed group requested extra POD 1 IV analgesics. Moreover, none of these patients experienced 30-day complications, and none of our patients required additional imaging studies or interventions as a cause of lengthier stays. In addition, we divided the cohort into tertiles and compared the tertile with the shortest LOS (median LOS 23 hours) with the highest LOS (median LOS 46 hours) (Table 4). The demographics were no differing between groups. In the comparison of POD1 parameters, similarly, we found that the significant factors were a higher VAS score with a lower patient score of 0 in the 3rd tertile group than in the 1st tertile group. The disadvantage is that we did not distinguish the nature of abdominal pain, and the clinical treatment of various pain types was roughly the same during the study period. Intragroup analysis revealed that those patients who required POD1 analgesics had a higher pain scale (2 (3–2) vs. 1 (2–1); p <0.001) and tended to be younger (33.0 years vs. 37.5 years; p=0.124) and female (71.4% vs. 59.6%; p=0.850), but the sample size was too small to reach statistical significance. Interestingly, younger patients (<40 years) and female patients were formerly recognized as independent factors associated with postoperative pain [27]. Because our analgesic regimen is solely based on one long-acting and another short-acting drug that complements each other, a more liberal use of perioperative nonopioid adjuvants at regular intervals independent of the severity of pain may offer improvements in patient satisfaction levels and further enhance early discharge [16]. There are likely many other uncontrollable factors that may change the willingness to discharge a patient, such as insurance reimbursement, distance [28] and patient choice [7], but the conditions were the same between the groups. Since the clinical team may have conflicting responsibilities on different days, a further analysis was performed to determine whether weekdays or weekends affect the timeliness of discharge. Paradoxically, more patients (17/48) in the early group were discharged on weekends than in the delay group (10/59) (p=0.049). Overall, there was a marginally shorter LOS for those discharged on weekends (n=27) than for those discharge on weekdays (n=80) (24 (25.5–23) hours vs. 26 (28–23) hours; p =0.08). Moreover, regarding the time of day the case concluded, a significantly more patients in early group (19/48) conclude their index operation after noon than delay group (11/59) (p<0.001). In other words, these factors that seem not conducive to discharge do not deter early discharge in the current research. On the other hand, while postoperative nausea/vomiting and dehydration are also common complications that discourage early discharge [29], remarkably, no patient in our study required POD1 anti-emetic drugs or had problems in oral hydration despite objective nausea scores not being evaluated in our study. Part of our success can be attributed to the full adherence to an established protocol consisting of a pre-emptive anti-emetic protocol, limited intravenous fluid administration, and the near total elimination of opioid use. Affected by the way the data presented, it appears the research discussion revolve around only 4 h difference in LOS. In fact, nearly half of the patients (24/59) in the delay group were discharged on POD2. As a community-based hospital with limited beds (total=284), we believe such advances have a significant impact on the flow of the ward and facilitate us to use limited resources more efficiently.

Table 4.

Surgical perspectives, outcomes, and POD1 parameters between tertiles

Variables	1st tertile	3rd tertile	P value
Operative duration (min), median (IQR)	89.5 (99.0–82.0)	92.0 (100.3–87.0)	0.573
LOS (hours), median (IQR)	23 (23–21)	46 (48–28)	< 0.001*
POD1 parameters
BT (°C), median (IQR)	36.6 (36.7–36.4)	36.6 (36.8–36.4)	0.843
PR (bpm), mean (SD)	73.0 (9.4)	71.3 (11.6)	0.506
RR (BPM), median (IQR)	16 (17–16)	17 (18–16)	0.365
SBP (mmHg), mean (SD)	125.5 (14.1)	122.3 (14.7)	0.375
WBC (103/ul), median (IQR)	12.70 (14.26–10.82)	12.83 (14.23–11.17)	0.942
> 14,000, n (%)	5 (13.9)	0 (0)	0.054
Neutrophil %, median (IQR)	77.5 (80.6–73.2)	77.9 (79.7–73.3)	0.991
> 85%, n (%)	3 (8.3)	1 (2.8)	0.614
Hb baseline (g/dl), median (IQR)	14.6 (15.4–14.0)	14.7 (16.1–13.9)	0.338
Hb POD1, median (IQR)	13.1 (13.8–12.5)	13.2 (14.1–12.5)	0.744
Hb decline >2, n (%)	4 (11.1)	10 (27.8)	0.137
CRP (mg/dl), median (IQR)	1.6 (2.3–1.3)	1.5 (2.4–1.1)	0.685
CRP >6, n (%)	3 (8.3)	1 (2.8)	0.614
VAS, median (IQR)	1 (1–0)	2 (2–1)	< 0.001*
VAS 0, n (%)	11 (30.6)	1 (2.8)	0.004*
Analgesics requirement, n (%)	1 (2.8)	5 (13.9)	0.199
Anti-emesis, n (%)	0	0	1.00
30-day ER visits, n (%)	1(2.8)	3 (8.3)	0.614
30-day readmission, n (%)	1(2.8)	1(2.8)	1.00
30-day complications, n (%)	1(2.8)	1(2.8)	1.00

BPM breaths per minute, BT body temperature, CRP C-reactive protein, ER emergency room, Hb hemoglobin, LOS length of stay, POD1 postoperative day one, PR pulse rate, RR respiratory rate, SBP systolic blood pressure, VAS Visual Analog Scale, WBC white blood cell

*P < 0.05

Limitations

Inherent to its retrospective and nonrandomized nature, selection bias cannot be completely eliminated. It is also possible that the differing nature of vague abdominal symptoms and subjective evaluation of pain scales based on different staff members are prone to inconsistent results. The lower BMI and relatively low-risk subgroup further limit the generalizability of our study. Although not ideally designed, the strengths of this study reside in the full adherence to a standard protocol, the surgery being performed by a single surgeon, and the study being conducted across a short time span. Therefore, the introduction of major flaws in this study from heterogeneous practices or from advances in surgical techniques and comprehensive care over time can largely be avoided.

In conclusion, our study favors the safety and feasibility of patient discharge within 24 h for low-risk patients in a low-volume setting. A more comprehensive protocol, such as administering additional nonopioid medications irrespective of the pain score, may further generalize this approach. Studies with more robust data and a longer follow-up should be performed in the future to support this discharge practice.