Literature DB >> 34802379

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.

Tsutomu Tanaka1, Blake M Warner2, Drew G Michael1, Hiroyuki Nakamura1, Toshio Odani1, Hongen Yin1, Tatsuya Atsumi3, Masayuki Noguchi4, John A Chiorini1.   

Abstract

ABBREVIATIONS: A253-control: A253 control for LAMP3 stable overexpression; A253- LAMP3: A253 LAPM3 stable overexpression; CASP1: caspase 1; CASP3: caspase 3; CHX: cycloheximide; CTSB: cathepsin B; CTSD: cathepsin D; CQ: chloroquine; DCs: dendritic cells; ER: endoplasmic reticulum; LGALS3: galectin 3; HCV: hepatitis C virus; HSG-control: HSG control for LAMP3 stable overexpression; HSG-LAMP3: HSG LAMP3 stable overexpression; HSP: heat shock protein; HTLV-1: human T-lymphocyte leukemia virus-1; IXA: ixazomib; LAMP: lysosomal associated membrane protein; MHC: major histocompatibility complex; mAb: monoclonal antibody; OE: overexpression; pepA: pepstatin A; pAb: polyclonal antibody; pSS: primary Sjögren syndrome; qRT-PCR: quantitative real- time reverse transcriptase polymerase chain reaction; SLE: systemic lupus erythematosus; SS: Sjögren syndrome; UPR: unfolded protein response; V-ATPase: vacuolar-type proton- translocating ATPase; Y-VAD: Ac-YVAD-cmk; Z-DEVD; Z-DEVD-fmk; Z-VAD: Z-VAD- fmk.

Entities:  

Keywords:  Apoptosis; Sjögren syndrome; autophagy; lysosomal membrane permeabilization; lysosome-associated membrane protein 3; salivary gland

Mesh:

Substances:

Year:  2021        PMID: 34802379      PMCID: PMC9298453          DOI: 10.1080/15548627.2021.1995150

Source DB:  PubMed          Journal:  Autophagy        ISSN: 1554-8627            Impact factor:   13.391


  99 in total

1.  Identification and characterization of novel adeno-associated virus isolates in ATCC virus stocks.

Authors:  Michael Schmidt; Emmanuelle Grot; Peter Cervenka; Sandra Wainer; Charles Buck; John A Chiorini
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

2.  Detection of HTLV-1 in the labial salivary glands of patients with Sjögren’s syndrome: a distinct clinical subgroup?

Authors:  Sung-Ji Lee; Ji Shin Lee; Myung-Geun Shin; Yuetsu Tanaka; Dong-Jin Park; Tae-Jong Kim; Yong-Wook Park; Shin-Seok Lee
Journal:  J Rheumatol       Date:  2012-03-01       Impact factor: 4.666

3.  Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome.

Authors:  Mi-Hyang Cho; Kwangmin Cho; Hoe-Jin Kang; Eun-Young Jeon; Hun-Sik Kim; Hyung-Joon Kwon; Hong-Mi Kim; Dong-Hou Kim; Seung-Yong Yoon
Journal:  Autophagy       Date:  2014-07-22       Impact factor: 16.016

4.  Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.

Authors:  Thomas Kirkegaard; Anke G Roth; Nikolaj H T Petersen; Ajay K Mahalka; Ole Dines Olsen; Irina Moilanen; Alicja Zylicz; Jens Knudsen; Konrad Sandhoff; Christoph Arenz; Paavo K J Kinnunen; Jesper Nylandsted; Marja Jäättelä
Journal:  Nature       Date:  2010-01-28       Impact factor: 49.962

5.  LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy.

Authors:  Anika Nagelkerke; Anieta M Sieuwerts; Johan Bussink; Fred C G J Sweep; Maxime P Look; John A Foekens; John W M Martens; Paul N Span
Journal:  Endocr Relat Cancer       Date:  2014-01-16       Impact factor: 5.678

6.  Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

Authors:  Nicole Fehrenbacher; Lone Bastholm; Thomas Kirkegaard-Sørensen; Bo Rafn; Trine Bøttzauw; Christina Nielsen; Ekkehard Weber; Senji Shirasawa; Tuula Kallunki; Marja Jäättelä
Journal:  Cancer Res       Date:  2008-08-15       Impact factor: 12.701

Review 7.  Endoplasmic reticulum stress and protein degradation in chronic liver disease.

Authors:  Si-Wei Xia; Zhi-Min Wang; Su-Min Sun; Ying Su; Zhang-Hao Li; Jiang-Juan Shao; Shan-Zhong Tan; An-Ping Chen; Shi-Jun Wang; Zi-Li Zhang; Feng Zhang; Shi-Zhong Zheng
Journal:  Pharmacol Res       Date:  2020-09-30       Impact factor: 7.658

8.  Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats.

Authors:  Yang Xu; Jingye Wang; Xinghui Song; Ruili Wei; Fangping He; Guoping Peng; Benyan Luo
Journal:  Brain Res Bull       Date:  2015-11-10       Impact factor: 4.077

9.  CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes.

Authors:  Bruno Salaun; Blandine de Saint-Vis; Nathalie Pacheco; Yves Pacheco; Arnaud Riesler; Sylvie Isaac; Caroline Leroux; Valérie Clair-Moninot; Jean-Jacques Pin; Janice Griffith; Isabelle Treilleux; Sophie Goddard; Jean Davoust; Monique Kleijmeer; Serge Lebecque
Journal:  Am J Pathol       Date:  2004-03       Impact factor: 4.307

10.  Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren's syndrome-like phenotype in mice.

Authors:  Hiroyuki Nakamura; Tsutomu Tanaka; Thomas Pranzatelli; Youngmi Ji; Hongen Yin; Paola Perez; Sandra A Afione; Shyh-Ing Jang; Corrine Goldsmith; Chang Yu Zheng; William D Swaim; Blake M Warner; Noriyuki Hirata; Masayuki Noguchi; Tatsuya Atsumi; John A Chiorini
Journal:  Ann Rheum Dis       Date:  2021-03-03       Impact factor: 19.103

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