Literature DB >> 34802119

Circulating T Follicular Helper Subsets in Human Blood.

Yayoi Iwamoto1, Hideki Ueno2,3.   

Abstract

CXCR5+ memory CD4+ T cells in human blood represent a circulating compartment of T follicular helper (Tfh) cells (termed circulating Tfh: cTfh cells). cTfh cells are composed of subsets that differ in phenotype and functions, and include resting and activated cell populations. Analysis of cTfh cell subsets have proven to be valuable to assess the ongoing global Tfh cell responses in vivo in distinct medical conditions including autoimmune diseases, infectious diseases, and after vaccination. Herein we will describe a detailed protocol to analyze cTfh subsets in human blood samples and to assess their helper capacity in culture with B cells.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Circulating T follicular helper cells; Human; Subsets

Mesh：

Substances：

Year:  2022        PMID： 34802119     DOI： 10.1007/978-1-0716-1736-6_3

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

1.  Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

Authors:  Jing He; Louis M Tsai; Yew Ann Leong; Xin Hu; Cindy S Ma; Nina Chevalier; Xiaolin Sun; Kirsten Vandenberg; Steve Rockman; Yan Ding; Lei Zhu; Wei Wei; Changqi Wang; Alexander Karnowski; Gabrielle T Belz; Joanna R Ghali; Matthew C Cook; D Sean Riminton; André Veillette; Pamela L Schwartzberg; Fabienne Mackay; Robert Brink; Stuart G Tangye; Carola G Vinuesa; Charles R Mackay; Zhanguo Li; Di Yu
Journal:  Immunity       Date:  2013-10-17       Impact factor: 31.745

2.  Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.

Authors:  Rimpei Morita; Nathalie Schmitt; Salah-Eddine Bentebibel; Rajaram Ranganathan; Laure Bourdery; Gerard Zurawski; Emile Foucat; Melissa Dullaers; SangKon Oh; Natalie Sabzghabaei; Elizabeth M Lavecchio; Marilynn Punaro; Virginia Pascual; Jacques Banchereau; Hideki Ueno
Journal:  Immunity       Date:  2011-01-06       Impact factor: 31.745

Review 3.  Pathophysiology of T follicular helper cells in humans and mice.

Authors:  Hideki Ueno; Jacques Banchereau; Carola G Vinuesa
Journal:  Nat Immunol       Date:  2015-02       Impact factor: 25.606

Review 4.  Phenotype and functions of memory Tfh cells in human blood.

Authors:  Nathalie Schmitt; Salah-Eddine Bentebibel; Hideki Ueno
Journal:  Trends Immunol       Date:  2014-07-03       Impact factor: 16.687

5.  Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.

Authors:  Michela Locci; Colin Havenar-Daughton; Elise Landais; Jennifer Wu; Mark A Kroenke; Cecilia L Arlehamn; Laura F Su; Rafael Cubas; Mark M Davis; Alessandro Sette; Elias K Haddad; Pascal Poignard; Shane Crotty
Journal:  Immunity       Date:  2013-09-12       Impact factor: 31.745

6.  ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination.

Authors:  Salah-Eddine Bentebibel; Surender Khurana; Nathalie Schmitt; Parvathi Kurup; Cynthia Mueller; Gerlinde Obermoser; A Karolina Palucka; Randy A Albrecht; Adolfo Garcia-Sastre; Hana Golding; Hideki Ueno
Journal:  Sci Rep       Date:  2016-05-27       Impact factor: 4.379

7.  Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection.

Authors:  Kristin L Boswell; Robert Paris; Eli Boritz; David Ambrozak; Takuya Yamamoto; Sam Darko; Kaska Wloka; Adam Wheatley; Sandeep Narpala; Adrian McDermott; Mario Roederer; Richard Haubrich; Mark Connors; Julie Ake; Daniel C Douek; Jerome Kim; Constantinos Petrovas; Richard A Koup
Journal:  PLoS Pathog       Date:  2014-01-30       Impact factor: 6.823
  7 in total
  2 in total

1.  An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques.

Authors:  Yongjun Sui; Jianping Li; Hanne Andersen; Roushu Zhang; Sunaina K Prabhu; Tanya Hoang; David Venzon; Anthony Cook; Renita Brown; Elyse Teow; Jason Velasco; Laurent Pessaint; Ian N Moore; Laurel Lagenaur; Jim Talton; Matthew W Breed; Josh Kramer; Kevin W Bock; Mahnaz Minai; Bianca M Nagata; Hyoyoung Choo-Wosoba; Mark G Lewis; Lai-Xi Wang; Jay A Berzofsky
Journal:  PNAS Nexus       Date:  2022-06-17

2.  CXCL13 expressed on inflamed cerebral blood vessels recruit IL-21 producing TFH cells to damage neurons following stroke.

Authors:  Aditya Rayasam; Julie A Kijak; Lee Kissel; Yun Hwa Choi; Taehee Kim; Martin Hsu; Dinesh Joshi; Collin J Laaker; Peter Cismaru; Anders Lindstedt; Krisztian Kovacs; Raghu Vemuganti; Shing Yan Chiu; Thanthrige Thiunuwan Priyathilaka; Matyas Sandor; Zsuzsanna Fabry
Journal:  J Neuroinflammation       Date:  2022-05-27       Impact factor: 9.587
  2 in total

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