François Avila1, Bénédicte Caron2, Gabriela Hossu3,4, Khalid Ambarki5, Stephan Kannengiesser6, Freddy Odille3,4, Jacques Felblinger3,4, Silvio Danese7, Myriam Choukour2, Valérie Laurent1,4, Laurent Peyrin-Biroulet8. 1. Department of Radiology, University Hospital of Nancy, Vandœuvre-lès-Nancy, France. 2. Department of Gastroenterology and NGERE, U1256 INSERM, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France. 3. CIC 1433 Innovation Technologique, INSERM, Université de Lorraine, , CHRU Nancy, Nancy, France. 4. IADI, U12454, INSERM, Université de Lorraine, CHRU Nancy, Nancy, France. 5. Siemens Healthcare SAS, Saint Denis, France. 6. MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany. 7. Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milano, Italy. 8. Department of Gastroenterology and NGERE, U1256 INSERM, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France. peyrinbiroulet@gmail.com.
Abstract
BACKGROUND: Patients with Crohn's disease can develop intestinal strictures, containing various degrees of inflammation and fibrosis. Differentiation of the main component of a stricturing lesion is the key for defining the therapeutic management. AIMS: We assessed for the first time the accuracy of magnetic resonance elastography in detecting intestinal fibrosis and predicting clinical course in patients with Crohn's disease. METHODS: This was a prospective study of adult patients with Crohn's disease and magnetic resonance imaging examination, including magnetic resonance elastography, between April 2019 and February 2020. The association between the bowel stiffness value and the degree of fibrosis was evaluated. The relationship between the stiffness value and the occurrence of clinical events was also investigated. RESULTS: A total of 69 patients were included. The stiffness value measured by magnetic resonance elastography was correlated with the degree of fibrosis (p < 0.001). A bowel stiffness ≥ 3.57 kPa predicted the occurrence of clinical events with an area under the curve of 0.82 (95% CI 0.71-0.93). Bowel stiffness ≥ 3.57 kPa was associated with an increased risk of clinical events (p < 0.0001). CONCLUSION: In Crohn's disease, magnetic resonance elastography is a reliable tool for detecting intestinal fibrosis and predicting a worse disease outcome.
BACKGROUND: Patients with Crohn's disease can develop intestinal strictures, containing various degrees of inflammation and fibrosis. Differentiation of the main component of a stricturing lesion is the key for defining the therapeutic management. AIMS: We assessed for the first time the accuracy of magnetic resonance elastography in detecting intestinal fibrosis and predicting clinical course in patients with Crohn's disease. METHODS: This was a prospective study of adult patients with Crohn's disease and magnetic resonance imaging examination, including magnetic resonance elastography, between April 2019 and February 2020. The association between the bowel stiffness value and the degree of fibrosis was evaluated. The relationship between the stiffness value and the occurrence of clinical events was also investigated. RESULTS: A total of 69 patients were included. The stiffness value measured by magnetic resonance elastography was correlated with the degree of fibrosis (p < 0.001). A bowel stiffness ≥ 3.57 kPa predicted the occurrence of clinical events with an area under the curve of 0.82 (95% CI 0.71-0.93). Bowel stiffness ≥ 3.57 kPa was associated with an increased risk of clinical events (p < 0.0001). CONCLUSION: In Crohn's disease, magnetic resonance elastography is a reliable tool for detecting intestinal fibrosis and predicting a worse disease outcome.