K Aoyagi1, J W Liew2, J T Farrar3, N Wang4, L Carlesso5, D Kumar6, L Frey Law7, C E Lewis8, M Nevitt9, T Neogi10. 1. Boston University School of Medicine, Boston, MA, USA. Electronic address: kaoyagi@bu.edu. 2. Boston University School of Medicine, Boston, MA, USA. Electronic address: jwliew@bu.edu. 3. University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address: jfarrar@pennmedicine.upenn.edu. 4. Boston University School of Public Health, Boston, MA, USA. Electronic address: nwang10@bu.edu. 5. McMaster University, ON, Canada. Electronic address: carlesl@mcmaster.ca. 6. Boston University School of Medicine, Boston, MA, USA. Electronic address: kumard@bu.edu. 7. University of Iowa, Iowa City, IA, USA. Electronic address: laura-freylaw@uiowa.edu. 8. University of Alabama, Birmingham, AL, USA. Electronic address: celewis@uabmc.edu. 9. University of California San Francisco, San Francisco, CA, USA. Electronic address: Michael.Nevitt@ucsf.edu. 10. Boston University School of Medicine, Boston, MA, USA. Electronic address: tneogi@bu.edu.
Abstract
OBJECTIVE: Knee osteoarthritis (OA) is predominantly characterized by pain with weight-bearing activities. Pain at rest also occurs but the mechanisms for this are not clear. We evaluated the relations of nociceptive signal alterations to weight-bearing and non-weight-bearing pain in knee OA. DESIGN: We used data from a NIH-funded longitudinal cohort of older adults with or at risk of knee OA. We evaluated quantitative sensory testing (QST) measures (pressure pain threshold (PPT) at patellae and the wrist; mechanical temporal summation (TS); conditioned pain modulation (CPM)). Each WOMAC pain question was dichotomized as having at least moderate pain, and we further categorized them as weight-bearing pain and non-weight-bearing pain. We evaluated the relation of QST measures to each pain outcome using logistic regression, adjusting for potential confounders. RESULTS: 2,749 participants (5,479 knees) were included (mean age 64 ± 11, 57% female). Each SD unit decrease in patellar PPT was associated with greater odds of both weight-bearing pain (OR 1.51 (95% CI 1.27, 1.79)) and non-weight-bearing pain (OR 1.46 (1.20-1.77)), while wrist PPT was associated with greater odds of weight-bearing pain (OR 1.27 (1.15, 1.39)) but only with pain during sitting/lying (OR 1.20 (1.01, 1.43)). TS was significantly associated with greater odds of pain with walking and stairs (OR 1.11 (1.01, 1.23), 1.11 (1.03, 1.20), respectively). CPM was not associated with any pain outcomes. CONCLUSIONS: Our findings challenge the hypothesis that non-weight-bearing pain may reflect greater pain sensitization and/or inefficient CPM than weight-bearing pain in knee OA, suggesting other mechanisms are likely responsible.
OBJECTIVE: Knee osteoarthritis (OA) is predominantly characterized by pain with weight-bearing activities. Pain at rest also occurs but the mechanisms for this are not clear. We evaluated the relations of nociceptive signal alterations to weight-bearing and non-weight-bearing pain in knee OA. DESIGN: We used data from a NIH-funded longitudinal cohort of older adults with or at risk of knee OA. We evaluated quantitative sensory testing (QST) measures (pressure pain threshold (PPT) at patellae and the wrist; mechanical temporal summation (TS); conditioned pain modulation (CPM)). Each WOMAC pain question was dichotomized as having at least moderate pain, and we further categorized them as weight-bearing pain and non-weight-bearing pain. We evaluated the relation of QST measures to each pain outcome using logistic regression, adjusting for potential confounders. RESULTS: 2,749 participants (5,479 knees) were included (mean age 64 ± 11, 57% female). Each SD unit decrease in patellar PPT was associated with greater odds of both weight-bearing pain (OR 1.51 (95% CI 1.27, 1.79)) and non-weight-bearing pain (OR 1.46 (1.20-1.77)), while wrist PPT was associated with greater odds of weight-bearing pain (OR 1.27 (1.15, 1.39)) but only with pain during sitting/lying (OR 1.20 (1.01, 1.43)). TS was significantly associated with greater odds of pain with walking and stairs (OR 1.11 (1.01, 1.23), 1.11 (1.03, 1.20), respectively). CPM was not associated with any pain outcomes. CONCLUSIONS: Our findings challenge the hypothesis that non-weight-bearing pain may reflect greater pain sensitization and/or inefficient CPM than weight-bearing pain in knee OA, suggesting other mechanisms are likely responsible.
Authors: David Yarnitsky; Lars Arendt-Nielsen; Didier Bouhassira; Robert R Edwards; Roger B Fillingim; Michal Granot; Per Hansson; Stefan Lautenbacher; Serge Marchand; Oliver Wilder-Smith Journal: Eur J Pain Date: 2010-03-12 Impact factor: 3.931
Authors: Lars Arendt-Nielsen; Hongling Nie; Mogens B Laursen; Birgitte S Laursen; Pascal Madeleine; Ole H Simonsen; Thomas Graven-Nielsen Journal: Pain Date: 2010-04-24 Impact factor: 6.961
Authors: Saeid Safiri; Ali-Asghar Kolahi; Emma Smith; Catherine Hill; Deepti Bettampadi; Mohammad Ali Mansournia; Damian Hoy; Ahad Ashrafi-Asgarabad; Mahdi Sepidarkish; Amir Almasi-Hashiani; Gary Collins; Jay Kaufman; Mostafa Qorbani; Maziar Moradi-Lakeh; Anthony D Woolf; Francis Guillemin; Lyn March; Marita Cross Journal: Ann Rheum Dis Date: 2020-05-12 Impact factor: 19.103
Authors: Laura A Frey-Law; Nicole L Bohr; Kathleen A Sluka; Keela Herr; Charles R Clark; Nicolas O Noiseux; John J Callaghan; M Bridget Zimmerman; Barbara A Rakel Journal: Pain Date: 2016-09 Impact factor: 7.926
Authors: Robert R Edwards; Andrew J Dolman; Marc O Martel; Patrick H Finan; Asimina Lazaridou; Marise Cornelius; Ajay D Wasan Journal: BMC Musculoskelet Disord Date: 2016-07-13 Impact factor: 2.362