James M Wilkins1, Joseph J Locascio2, Teresa Gomez-Isla3, Bradley T Hyman3, Deborah Blacker4, Brent P Forester5, Olivia I Okereke4. 1. McLean Hospital, Belmont, MA; Harvard Medical School, Boston, MA. Electronic address: jwilkins1@partners.org. 2. Massachusetts Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Harvard Catalyst Biostatistical Consulting, Harvard Catalyst/CTSA; Harvard Medical School, Boston, MA. 3. Massachusetts Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. 4. Massachusetts Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. 5. McLean Hospital, Belmont, MA; Harvard Medical School, Boston, MA.
Abstract
OBJECTIVES: Neuropsychiatric symptoms (NPS) of dementia are common and may be driven by inability of persons with cognitive impairment (CI) to communicate needs. We addressed the relevance of this unmet-needs model to burden of NPS among persons with milder CI. METHODS: The sample included 48 dyads of persons with CI and their care partners. NPS were measured at baseline and follow-up (mean 486 days +/-107 SD). Mixed random and fixed effects longitudinal models were used to evaluate impact of discrepancies between persons with CI and their care partners in everyday preferences (baseline) on changes in NPS over time. RESULTS: Higher levels of underestimation of "social engagement" preferences of persons with CI by care partners were associated with a higher average burden of NPS across all follow-up. CONCLUSIONS: This study suggests that unmet-needs may be a useful construct for understanding etiology for NPS across the spectrum of severity of cognitive impairment.
OBJECTIVES: Neuropsychiatric symptoms (NPS) of dementia are common and may be driven by inability of persons with cognitive impairment (CI) to communicate needs. We addressed the relevance of this unmet-needs model to burden of NPS among persons with milder CI. METHODS: The sample included 48 dyads of persons with CI and their care partners. NPS were measured at baseline and follow-up (mean 486 days +/-107 SD). Mixed random and fixed effects longitudinal models were used to evaluate impact of discrepancies between persons with CI and their care partners in everyday preferences (baseline) on changes in NPS over time. RESULTS: Higher levels of underestimation of "social engagement" preferences of persons with CI by care partners were associated with a higher average burden of NPS across all follow-up. CONCLUSIONS: This study suggests that unmet-needs may be a useful construct for understanding etiology for NPS across the spectrum of severity of cognitive impairment.
Authors: D I Kaufer; J L Cummings; P Ketchel; V Smith; A MacMillan; T Shelley; O L Lopez; S T DeKosky Journal: J Neuropsychiatry Clin Neurosci Date: 2000 Impact factor: 2.198
Authors: James M Wilkins; Joseph J Locascio; Jeanette M Gunther; Teresa Gomez-Isla; Bradley T Hyman; Deborah Blacker; Brent P Forester; Olivia I Okereke Journal: Int J Geriatr Psychiatry Date: 2021-09-08 Impact factor: 3.485
Authors: James M Wilkins; Joseph J Locascio; Jeanette M Gunther; Liang Yap; Bradley T Hyman; Deborah Blacker; Brent P Forester; Olivia I Okereke Journal: Am J Geriatr Psychiatry Date: 2020-02-06 Impact factor: 4.105