Literature DB >> 34800413

Trials for neurodegenerative diseases: time to innovate.

Arpan R Mehta, Jeremy Chataway, Suvankar Pal, Mahesh K B Parmar, Siddharthan Chandran.   

Abstract

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Mesh：

Year:  2021        PMID： 34800413      PMCID： PMC7612114          DOI： 10.1016/S1474-4422(21)00388-4

Source DB:  PubMed          Journal:  Lancet Neurol        ISSN： 1474-4422            Impact factor:   59.935


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  1 in total

1.  Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.

Authors:  Mahesh Kb Parmar; Matthew R Sydes; Fay H Cafferty; Babak Choodari-Oskooei; Ruth E Langley; Louise Brown; Patrick Pj Phillips; Melissa R Spears; Sam Rowley; Richard Kaplan; Nicholas D James; Timothy Maughan; Nicholas Paton; Patrick J Royston
Journal:  Clin Trials       Date:  2017-08-22       Impact factor: 2.486
  1 in total
  3 in total

1.  Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.

Authors:  Charis Wong; Rachel S Dakin; Jill Williamson; Judith Newton; Michelle Steven; Shuna Colville; Maria Stavrou; Jenna M Gregory; Elizabeth Elliott; Arpan R Mehta; Jeremy Chataway; Robert J Swingler; Richard Anthony Parker; Christopher J Weir; Nigel Stallard; Mahesh K B Parmar; Malcolm R Macleod; Suvankar Pal; Siddharthan Chandran
Journal:  BMJ Open       Date:  2022-07-07       Impact factor: 3.006

2.  Advances in Neurodegenerative Diseases.

Authors:  Vasileios Siokas; Efthimios Dardiotis
Journal:  Neurol Int       Date:  2022-03-28

3.  "Calcium bombs" as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions.

Authors:  Kosala N Dissanayake; Robert R Redman; Harry Mackenzie; Michael Eddleston; Richard R Ribchester
Journal:  Front Mol Neurosci       Date:  2022-07-26       Impact factor: 6.261
  3 in total

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