Literature DB >> 3479749

A human Y-chromosomal DNA sequence expressed in testicular tissue.

J Arnemann1, J T Epplen, H J Cooke, U Sauermann, W Engel, J Schmidtke.   

Abstract

Clone pJA36B (DYS14) was isolated from a human Y chromosome enriched cosmid library. Southern blot analysis revealed a male-specific hybridization pattern. Deletion mapping with patients' DNA localized pJA36B to the median region of Yp, being present in the DNA of nine of fifteen XX-males tested so far and therefore localized in the region neighbouring the TDF-locus. Northern blot analysis showed a transcription signal in poly(A)+ RNA of human testis. Sequence analysis of the genomic DNA sequence revealed an open reading frame of 522 basepairs in the absence of control or signal sequences for the regulation of transcription or polyadenylation. This suggests that only one exon of a translatable sequence is present in clone pJA36B. A computer aided search revealed no significant homologies with known DNA or protein sequences.

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Year:  1987        PMID： 3479749      PMCID： PMC306400          DOI： 10.1093/nar/15.21.8713

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  30 in total

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Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
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Journal:  Nucleic Acids Res       Date:  1986-08-26       Impact factor: 16.971

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Journal:  J Mol Biol       Date:  1980-10-25       Impact factor: 5.469

Review 4.  A synopsis of the human Y chromosome.

Authors:  E M Bühler
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

Review 5.  Localisation of male determining factors in man: a thorough review of structural anomalies of the Y chromosome.

Authors:  R M Davis
Journal:  J Med Genet       Date:  1981-06       Impact factor: 6.318

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Authors:  L Singh; I F Purdom; K W Jones
Journal:  Chromosoma       Date:  1980       Impact factor: 4.316

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Authors:  P S Burgoyne
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

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Authors:  L Singh; K W Jones
Journal:  Cell       Date:  1982-02       Impact factor: 41.582

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Authors:  G Guellaen; M Casanova; C Bishop; D Geldwerth; G Andre; M Fellous; J Weissenbach
Journal:  Nature       Date:  1984 Jan 12-18       Impact factor: 49.962
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  29 in total

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7.  Prenatal sex determination from maternal peripheral blood using the polymerase chain reaction.

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