Nader Salari1, Habibolah Khazaie1, Maryam Abolfathi2, Hooman Ghasemi3, Shervin Shabani3, Shna Rasoulpoor3, Masoud Mohammadi4, Shabnam Rasoulpoor3, Behnam Khaledi-Paveh1. 1. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. 3. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. 4. Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran. masoud.mohammadi1989@yahoo.com.
Abstract
BACKGROUND: Obstructive sleep apnea (OSA) is a disorder characterized by intermittent airway obstruction during sleep. The association between OSA and the incidence of cardiovascular disease (CVD) has been investigated in many studies; however, the results are not entirely consistent between studies. The aim of this study was to investigate the relationship between OSA and the risk of CVD through a meta-analysis of cohort studies. METHODS: A systematic review and meta-analysis of literature was conducted using the PubMed, WoS, Embase, ScienceDirect, Scopus, and Web of Science databases up to the year 2020. In order to analyze the eligible studies, the stochastic effects model was used and the heterogeneity of the studies with the I2 index was investigated. Data analysis was performed with Comprehensive Meta-Analysis software (Version 2). RESULTS: A total of 24 studies were included in the meta-analysis according to the inclusion criteria. Twelve studies reported CVD results, 11 studies reported stroke results, 9 studies reported mortality results, and 8 studies reported CVD results. The odds ratio of CVD in patients with OSA 1.71 (1.17-2.27: 95% confidence interval) stroke in patients with OSA, 1.86 (1.28-2.69: 95% confidence interval), mortality in patients with OSA, 1.77 (1.37-2.29: 95% confidence interval) and CHD in patients with OSA, and 1.48 (1.06-2.28: 95% confidence interval) was obtained. CONCLUSION: OSA is considered a cardiovascular risk factor. There is a relationship between the severity of OSA and the risk of cardiovascular disease. OSA increases the risk of heart attack, CHD, and death from cardiovascular disease.
BACKGROUND: Obstructive sleep apnea (OSA) is a disorder characterized by intermittent airway obstruction during sleep. The association between OSA and the incidence of cardiovascular disease (CVD) has been investigated in many studies; however, the results are not entirely consistent between studies. The aim of this study was to investigate the relationship between OSA and the risk of CVD through a meta-analysis of cohort studies. METHODS: A systematic review and meta-analysis of literature was conducted using the PubMed, WoS, Embase, ScienceDirect, Scopus, and Web of Science databases up to the year 2020. In order to analyze the eligible studies, the stochastic effects model was used and the heterogeneity of the studies with the I2 index was investigated. Data analysis was performed with Comprehensive Meta-Analysis software (Version 2). RESULTS: A total of 24 studies were included in the meta-analysis according to the inclusion criteria. Twelve studies reported CVD results, 11 studies reported stroke results, 9 studies reported mortality results, and 8 studies reported CVD results. The odds ratio of CVD in patients with OSA 1.71 (1.17-2.27: 95% confidence interval) stroke in patients with OSA, 1.86 (1.28-2.69: 95% confidence interval), mortality in patients with OSA, 1.77 (1.37-2.29: 95% confidence interval) and CHD in patients with OSA, and 1.48 (1.06-2.28: 95% confidence interval) was obtained. CONCLUSION: OSA is considered a cardiovascular risk factor. There is a relationship between the severity of OSA and the risk of cardiovascular disease. OSA increases the risk of heart attack, CHD, and death from cardiovascular disease.
Authors: Melissa S Oh; Donald L Bliwise; Andrew L Smith; Nancy A Collop; Arshed A Quyyumi; Raj C Dedhia Journal: Laryngoscope Date: 2019-09-18 Impact factor: 3.325
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