| Literature DB >> 34797450 |
E V Inzhevatkin1,2, A V Baron3, M B Volkova4, N G Maksimov5, N K Golubenko6, M V Loshkareva7, A P Puzyr'7,3, N O Ronzhin3, V S Bondar3.
Abstract
Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.Entities:
Keywords: EPR-spectrometry; biochemical changes in blood plasma; biodistribution; detonation synthesis nanodiamonds; intravenous administration
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Year: 2021 PMID： 34797450 DOI： 10.1007/s10517-021-05335-9
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804