Literature DB >> 34796277

The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni.

Warwick Grant1, Stephen R Doyle2, Kirsty McCann1.   

Abstract

We present a genome assembly and annotation of an individual female Cercopithifilaria johnstoni, a parasitic filarial nematode that is transmitted by hard ticks (Ixodidae) to infect a broad range of native Australian murid and marsupial hosts. The genome sequence is 76.9 Mbp in length, and although in draft form (N50 = 99 kbp, N50[n] = 232), is largely complete based on universally conserved orthologs (BUSCOs; genome = 94.9%, protein = 96.5%) and relative to other related filarial species. These data represent the first genomic resources for the genus Cercopithifilaria, a group of parasites with a broad host range, and form the basis for comparative analysis with the human-infective parasite, Onchocerca volvulus, both of which are responsible for similar eye and skin pathologies in their respective hosts. Copyright:
© 2021 McCann K et al.

Entities:  

Keywords:  Cercopithifilaria johnstoni; Illumina MiSeq; filarial nematode; genome assembly

Year:  2021        PMID: 34796277      PMCID: PMC8564745.2          DOI: 10.12688/wellcomeopenres.17258.2

Source DB:  PubMed          Journal:  Wellcome Open Res        ISSN: 2398-502X


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