| Literature DB >> 34792719 |
I V Babushkina1, I A Mamonova2, V Yu Ulyanov2, E V Gladkova2, S P Shpinyak2.
Abstract
Comparison of activity of antibiotics against Staphylococcus aureus strains in their plankton form and in biofilms of varying maturity showed that the concentrations of antibiotics causing death of 90% S. aureus strains (MIC90) in their plankton form was 0.07-2.80 μg/ml and significantly (p<0.05) differed from MIC90 concentrations (3-245 μg/ml) for the strains in 24 and 48 h biofilms. MIC90 value was affected by the degree of biofilm maturity: microbial resistance in 48-h biofilms for all analyzed antibiotics was significantly (p<0.05) higher than in 24-h biofilms.Entities:
Keywords: Staphylococcus aureus; antibiotics; implant-associated infection; preformed biofilms
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Year: 2021 PMID： 34792719 DOI： 10.1007/s10517-021-05328-8
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804