| Literature DB >> 34791884 |
Yi Cui1, Jun Ren1, Jiayuan Lv1, Zhongwen Wang1.
Abstract
An efficient construction of an aza-[5.7.6.5] tetracyclic core structure of calyciphylline D-type Daphniphyllum alkaloids has been achieved. The synthetic route features a diastereoselective cyclopropanation, efficient construction of the core bridged 8-aza-[3.2.1]octane skeleton through a [3 + 2] IMCC strategy, oxidative dearomatization of phenol, and gram-scale preparation in each step.Entities:
Year: 2021 PMID： 34791884 DOI： 10.1021/acs.orglett.1c03497
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005