Literature DB >> 347886

L-tryptophan and 5-hydroxytryptophan in the treatment of depression. A review.

G d'Elia, L Hanson, H Raotma.   

Abstract

Trials performed do not provide evidence for an antidepressant effect of 5-HTP. L-TP, without interacting pharmaca, does not appear to be a well-documented antidepressant. The only convincing evidence for L-TP as an antidepressant is that L-TP enhances the effect of MAOI.

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Year:  1978        PMID： 347886     DOI： 10.1111/j.1600-0447.1978.tb06890.x

Source DB:  PubMed          Journal:  Acta Psychiatr Scand        ISSN： 0001-690X            Impact factor:   6.392


  9 in total

1.  Metabolism of an oral tryptophan load. I: Effects of dose and pretreatment with tryptophan.

Authors:  A R Green; J K Aronson; G Curzon; H F Woods
Journal:  Br J Clin Pharmacol       Date:  1980-12       Impact factor: 4.335

2.  Increased serum glutamate in depressed patients.

Authors:  J S Kim; W Schmid-Burgk; D Claus; H H Kornhuber
Journal:  Arch Psychiatr Nervenkr (1970)       Date:  1982

Review 3.  L-kynurenine: its synthesis and possible regulatory function in brain.

Authors:  E M Gál; A D Sherman
Journal:  Neurochem Res       Date:  1980-03       Impact factor: 3.996

4.  Tryptophan tolerance and metabolism in endogenous depression.

Authors:  S E Møller; L Kirk; P Honoré
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

5.  Kinetics of L-tryptophan in depressive patients: a possible correlation between the plasma concentrations of L-tryptophan and some psychiatric rating scales.

Authors:  M J Hoes; T Loeffen; T B Vree
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

6.  Pharmacokinetics of tryptophan, renal handling of kynurenine and the effect of nicotinamide on its appearance in plasma and urine following L-tryptophan loading of healthy subjects.

Authors:  S E Møller
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953

Review 7.  Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness.

Authors:  R C Heel; P A Morley; R N Brogden; A A Carmine; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-09       Impact factor: 9.546

8.  Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.

Authors:  Gerard Honig; Minke E Jongsma; Marieke C G van der Hart; Laurence H Tecott
Journal:  PLoS One       Date:  2009-08-27       Impact factor: 3.240

9.  5-HTP efficacy and contraindications.

Authors:  Marty Hinz; Alvin Stein; Thomas Uncini
Journal:  Neuropsychiatr Dis Treat       Date:  2012-07-19       Impact factor: 2.570
  9 in total

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