| Literature DB >> 34788508 |
Adel Mandl1, Peter D Burbelo1, Giovanni Di Pasquale1, You Sher Tay1, James Welch1, Michail S Lionakis1, Sergio D Rosenzweig1, Meryl A Waldman1, Blake M Warner1, Brian Walitt1, Michael T Collins1, James E Balow1, John A Chiorini1, William F Simonds1, Sunita K Agarwal1, Jenny E Blau1, Lee S Weinstein1.
Abstract
We describe two cases of acquired parathyroid hormone (PTH) resistance consequent to the development of serum PTH type 1 receptor (PTH1R) autoantibodies, which block PTH binding and signaling. Both cases were associated with other autoimmune manifestations, and one case was associated with atypical membranous glomerulonephritis. In vitro binding and signaling assays identified the presence of PTH1R-blocking IgG autoantibodies, which were not present in serum samples from patients with other renal or autoimmune disorders. (Funded by the Intramural Research Programs of the National Institute of Diabetes and Digestive and Kidney Diseases and others.).Entities:
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Year: 2021 PMID： 34788508 PMCID： PMC9088239 DOI： 10.1056/NEJMoa2109409
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 176.079