| Literature DB >> 34787818 |
Divya K Vijayan1,2, P R Sreerekha1,3, Pavan Kumar Dara1, B Ganesan1, Suseela Mathew1, Rangasamy Anandan4, C N Ravisankar1.
Abstract
The aim of the present study was to investigate the ability of fish collagen peptides (FCP) from the skin of great hammerhead shark (Sphyrna mokarran) to avert the occurrence of gastric ulcer in experimental rats. FCP treatment prevented the formation of ulcerative lesions on gastric tissues with 86% of inhibition. The histopathology analysis of gastric tissue revealed that the FCP intake prevented the occurrence of hemorrhage and erosion in gastric tissue with formation of mild edema and necrosis, as well as normalized the pH and volume of gastric juice. It also downregulated the expression of pro-inflammatory marker interferon-ɤ (IFN-ɤ) and upregulated the anti-inflammatory marker interleukin-4 (IL-4) in gastric tissue. FCP is capable to modulate the oxidative stress by enhancing the activity of antioxidant defense enzymes superoxide dismutase (SOD) and catalase and by lowering the levels of membrane lipid peroxidation.Entities:
Keywords: Bioactivity; Gastroprotective; Great hammerhead shark; Gross pathology; Histopathology; Inflammatory markers
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Year: 2021 PMID： 34787818 PMCID： PMC8821750 DOI： 10.1007/s12192-021-01245-x
Source DB: PubMed Journal: Cell Stress Chaperones ISSN： 1355-8145 Impact factor: 3.827