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Literature DB >> 34786671

Methods for the Development of Recombinant Microorganisms for the Production of Natural Products.

Alexander Perl¹, Hunter Dalton², YeJong Yoo², Mattheos A G Koffas^3,4.

Abstract

Metabolic engineering strives to develop microbial strains that are capable of producing a target chemical in a biological organism. There are still many challenges to overcome in order to achieve titers, yields, and productivities necessary for industrial production. The use of recombinant microorganisms to meet these needs is the next step for metabolic engineers. In this chapter, we aim to provide insight on both the applications of metabolic engineering for natural product biosynthesis as well as optimization methods.

Entities: Chemical

Keywords: Metabolic engineering; Natural products; Recombinant microorganisms

Mesh：

Substances：
Biological Products

Year: 2022 PMID： 34786671 DOI： 10.1007/978-1-0716-1822-6_1

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

49 in total

1. Monitoring of genes that respond to process-related stress in large-scale bioprocesses.

Authors: T Schweder; E Krüger; B Xu; B Jürgen; G Blomsten; S O Enfors; M Hecker
Journal: Biotechnol Bioeng Date: 1999-10-20 Impact factor: 4.530

2. Physiological responses to mixing in large scale bioreactors.

Authors: S O Enfors; M Jahic; A Rozkov; B Xu; M Hecker; B Jürgen; E Krüger; T Schweder; G Hamer; D O'Beirne; N Noisommit-Rizzi; M Reuss; L Boone; C Hewitt; C McFarlane; A Nienow; T Kovacs; C Trägårdh; L Fuchs; J Revstedt; P C Friberg; B Hjertager; G Blomsten; H Skogman; S Hjort; F Hoeks; H Y Lin; P Neubauer; R van der Lans; K Luyben; P Vrabel; A Manelius
Journal: J Biotechnol Date: 2001-02-13 Impact factor: 3.307

Review 3. Expanding the metabolic engineering toolbox: more options to engineer cells.

Authors: Keith E Tyo; Hal S Alper; Gregory N Stephanopoulos
Journal: Trends Biotechnol Date: 2007-01-24 Impact factor: 19.536

4. Engineering static and dynamic control of synthetic pathways.

Authors: William J Holtz; Jay D Keasling
Journal: Cell Date: 2010-01-08 Impact factor: 41.582

Review 5. Synthetic biology and metabolic engineering.

Authors: Gregory Stephanopoulos
Journal: ACS Synth Biol Date: 2012-11-16 Impact factor: 5.110

6. Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs.

Authors: T Xia; J SantaLucia; M E Burkard; R Kierzek; S J Schroeder; X Jiao; C Cox; D H Turner
Journal: Biochemistry Date: 1998-10-20 Impact factor: 3.162

1. Protein Engineering of a Germacrene A Synthase From Lactuca sativa and Its Application in High Productivity of Germacrene A in Escherichia coli.

Authors: Rong Chen; Yuheng Liu; Shu Chen; Ming Wang; Yao Zhu; Tianyuan Hu; Qiuhui Wei; Xiaopu Yin; Tian Xie
Journal: Front Plant Sci Date: 2022-08-11 Impact factor: 6.627

1 in total

Methods for the Development of Recombinant Microorganisms for the Production of Natural Products.

1. Monitoring of genes that respond to process-related stress in large-scale bioprocesses.

2. Physiological responses to mixing in large scale bioreactors.

Review 3. Expanding the metabolic engineering toolbox: more options to engineer cells.

4. Engineering static and dynamic control of synthetic pathways.

Review 5. Synthetic biology and metabolic engineering.

6. Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs.

7. Engineering cell wall synthesis mechanism for enhanced PHB accumulation in E. coli.

Review 8. Impact of CRISPR interference on strain development in biotechnology.

9. High-efficiency multiplex genome editing of Streptomyces species using an engineered CRISPR/Cas system.

10. CRISPRi-mediated metabolic engineering of E. coli for O-methylated anthocyanin production.

1. Protein Engineering of a Germacrene A Synthase From Lactuca sativa and Its Application in High Productivity of Germacrene A in Escherichia coli.