| Literature DB >> 34785406 |
Graham M L Eglit1, Jeremy A Elman2, Mathew S Panizzon2, Mark Sanderson-Cimino3, McKenna E Williams3, Anders M Dale4, Lisa T Eyler5, Christine Fennema-Notestine6, Nathan A Gillespie7, Daniel E Gustavson2, Sean N Hatton8, Donald J Hagler9, Richard L Hauger10, Amy J Jak11, Mark W Logue12, Linda K McEvoy9, Ruth E McKenzie13, Michael C Neale7, Olivia Puckett2, Chandra A Reynolds14, Rosemary Toomey15, Xin M Tu2, Nathan Whitsel2, Hong Xian16, Michael J Lyons17, Carol E Franz17, William S Kremen18.
Abstract
Because longitudinal studies of aging typically lack cognitive data from earlier ages, it is unclear how general cognitive ability (GCA) changes throughout the life course. In 1173 Vietnam Era Twin Study of Aging (VETSA) participants, we assessed young adult GCA at average age 20 and current GCA at 3 VETSA assessments beginning at average age 56. The same GCA index was used throughout. Higher young adult GCA and better GCA maintenance were associated with stronger specific cognitive abilities from age 51 to 73. Given equivalent GCA at age 56, individuals who had higher age 20 GCA outperformed those whose GCA remained stable in terms of memory, executive function, and working memory abilities from age 51 to 73. Thus, paradoxically, despite poorer maintenance of GCA, high young adult GCA still conferred benefits. Advanced predicted brain age and the combination of elevated vascular burden and APOE-ε4 status were associated with poorer maintenance of GCA. These findings highlight the importance of distinguishing between peak and current GCA for greater understanding of cognitive aging. Published by Elsevier Inc.Entities:
Keywords: Cognitive aging; Dementia; General cognitive ability; Longitudinal studies; Neuropsychology
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Year: 2021 PMID： 34785406 PMCID： PMC8715388 DOI： 10.1016/j.neurobiolaging.2021.10.002
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673