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Literature DB >> 34784038

Production, Isolation, and Characterization of Bioengineered Bacterial Extracellular Membrane Vesicles Derived from Bacteroides thetaiotaomicron and Their Use in Vaccine Development.

Régis Stentz¹, Ariadna Miquel-Clopés¹, Simon R Carding².

Abstract

Bacterial extracellular vesicles (BEVs) possess features that make them well suited for the delivery of therapeutics and vaccines. This chapter describes methods for engineering the commensal human intestinal bacterium Bacteroides thetaiotaomicron (Bt) to produce BEVs carrying vaccine antigens and accompanying methods for isolating and purifying BEVs for mucosal vaccination regimens.

Entities: Chemical

Keywords: Bacterial extracellular vesicles; Bacteroides thetaiotaomicron; Crossflow ultrafiltration; Immunization; Vaccines

Mesh：

Year: 2022 PMID： 34784038 DOI： 10.1007/978-1-0716-1900-1_11

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

18 in total

1. Delivery of foreign antigens by engineered outer membrane vesicle vaccines.

Authors: David J Chen; Nikolaus Osterrieder; Stephan M Metzger; Elizabeth Buckles; Anne M Doody; Matthew P DeLisa; David Putnam
Journal: Proc Natl Acad Sci U S A Date: 2010-01-27 Impact factor: 11.205

2. Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization.

Authors: Gaurav Kanojia; René H M Raeven; Larissa van der Maas; Tim H E Bindels; Elly van Riet; Bernard Metz; Peter C Soema; Rimko Ten Have; Henderik W Frijlink; Jean-Pierre Amorij; Gideon F A Kersten
Journal: J Control Release Date: 2018-07-24 Impact factor: 9.776

Review 3. COVID-19 vaccine development and a potential nanomaterial path forward.

Authors: Matthew D Shin; Sourabh Shukla; Young Hun Chung; Veronique Beiss; Soo Khim Chan; Oscar A Ortega-Rivera; David M Wirth; Angela Chen; Markus Sack; Jonathan K Pokorski; Nicole F Steinmetz
Journal: Nat Nanotechnol Date: 2020-07-15 Impact factor: 39.213

Review 4. Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions.

Authors: Carmen Schwechheimer; Meta J Kuehn
Journal: Nat Rev Microbiol Date: 2015-10 Impact factor: 60.633

5. Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines.

Authors: Carmen Arigita; Wim Jiskoot; Janny Westdijk; Cor van Ingen; Wim E Hennink; Daan J A Crommelin; Gideon F A Kersten
Journal: Vaccine Date: 2004-01-26 Impact factor: 3.641

Review 6. Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body.

Authors: Régis Stentz; Ana L Carvalho; Emily J Jones; Simon R Carding
Journal: Biochem Soc Trans Date: 2018-08-28 Impact factor: 5.407

Review 7. Novel approaches for the design, delivery and administration of vaccine technologies.

Authors: J Wallis; D P Shenton; R C Carlisle
Journal: Clin Exp Immunol Date: 2019-04-08 Impact factor: 4.330

8. Bioengineering commensal bacteria-derived outer membrane vesicles for delivery of biologics to the gastrointestinal and respiratory tract.

Authors: Ana L Carvalho; Sonia Fonseca; Ariadna Miquel-Clopés; Kathryn Cross; Khoon-S Kok; Udo Wegmann; Katherine Gil-Cordoso; Eleanor G Bentley; Sanaria H M Al Katy; Janine L Coombes; Anja Kipar; Regis Stentz; James P Stewart; Simon R Carding
Journal: J Extracell Vesicles Date: 2019-06-24