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Literature DB >> 34783983

A Breakthrough in Understanding the Rapid Antidepressant Effect of Ketamine Based on Structural Analysis.

Hongmei Liu¹, Xiaohui Wu¹, Jun Chen^1,2, Yiru Fang^3,4,5.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2021 PMID： 34783983 PMCID： PMC8821759 DOI： 10.1007/s12264-021-00794-6

Source DB: PubMed Journal: Neurosci Bull ISSN： 1995-8218 Impact factor: 5.203

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Authors: Yamin Yao; Peijun Ju; Hongmei Liu; Xiaohui Wu; Zhiang Niu; Yuncheng Zhu; Chen Zhang; Yiru Fang
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Journal: Am J Psychiatry Date: 2006-11 Impact factor: 18.112

A Breakthrough in Understanding the Rapid Antidepressant Effect of Ketamine Based on Structural Analysis.

Review 1. Depression.

2. Effects of a ketamine metabolite on synaptic NMDAR function.

3. Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder.

4. Ifenprodil rapidly ameliorates depressive-like behaviors, activates mTOR signaling and modulates proinflammatory cytokines in the hippocampus of CUMS rats.

5. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report.

Review 6. Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy.

7. Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors.

8. Structural basis of ketamine action on human NMDA receptors.

Review 9. Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications.

10. Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors.