Hadas Miremberg1,2, Hadas Ganer Herman3,4, Mor Bustan3,4, Eran Weiner3,4, Letizia Schreiber5,4, Jacob Bar3,4, Michal Kovo3,4. 1. Departments of Obstetrics and Gynecology, The Edith Wolfson Medical Center, P.O Box 5, 58100, Holon, Israel. dasile2@gmail.com. 2. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. dasile2@gmail.com. 3. Departments of Obstetrics and Gynecology, The Edith Wolfson Medical Center, P.O Box 5, 58100, Holon, Israel. 4. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 5. Department of Pathology, The Edith Wolfson Medical Center, Holon, Israel.
Abstract
PURPOSE: A growing body of evidence accumulate pointing to sex-specific differences in placental adaptation to pregnancy complications. We aimed to study if there is a difference in placental histopathology lesions, between female and male fetuses in pregnancies complicated with preeclampsia. METHODS: The medical files of all patients with preeclampsia, were reviewed. Placental lesions were classified to lesions related to maternal or fetal malperfusion lesions (MVM, FVM), vascular and villous changes, and inflammatory lesions. Comparison was performed between the male and the female groups. RESULTS: The study included 441 preeclamptic patients. Women in the male preeclampsia group (n = 225) had higher rate of chronic hypertension (p = 0.05) and diabetes mellitus (p < 0.005), while women in the female preeclampsia group (n = 216) had higher rate of thrombophilia. There were no between groups differences in neonatal outcome or placental histopathology lesions. The early preeclampsia cohort included 91 patients. Placentas from the female early preeclampsia group (n = 44) had more vascular changes related to MVM lesions (decidual arteriopathy), as compared to the male early preeclampsia group (n = 47), 50% vs. 25%, p = 0.01. CONCLUSIONS: Higher rate of placental MVM lesions in the female as compared to male group correspond with sex-specific difference of placental pathophysiological adaptation, in early preeclampsia.
PURPOSE: A growing body of evidence accumulate pointing to sex-specific differences in placental adaptation to pregnancy complications. We aimed to study if there is a difference in placental histopathology lesions, between female and male fetuses in pregnancies complicated with preeclampsia. METHODS: The medical files of all patients with preeclampsia, were reviewed. Placental lesions were classified to lesions related to maternal or fetal malperfusion lesions (MVM, FVM), vascular and villous changes, and inflammatory lesions. Comparison was performed between the male and the female groups. RESULTS: The study included 441 preeclamptic patients. Women in the male preeclampsia group (n = 225) had higher rate of chronic hypertension (p = 0.05) and diabetes mellitus (p < 0.005), while women in the female preeclampsia group (n = 216) had higher rate of thrombophilia. There were no between groups differences in neonatal outcome or placental histopathology lesions. The early preeclampsia cohort included 91 patients. Placentas from the female early preeclampsia group (n = 44) had more vascular changes related to MVM lesions (decidual arteriopathy), as compared to the male early preeclampsia group (n = 47), 50% vs. 25%, p = 0.01. CONCLUSIONS: Higher rate of placental MVM lesions in the female as compared to male group correspond with sex-specific difference of placental pathophysiological adaptation, in early preeclampsia.
Authors: Tamara Garrido-Gomez; Francisco Dominguez; Alicia Quiñonero; Patricia Diaz-Gimeno; Mirhan Kapidzic; Matthew Gormley; Katherine Ona; Pablo Padilla-Iserte; Michael McMaster; Olga Genbacev; Alfredo Perales; Susan J Fisher; Carlos Simón Journal: Proc Natl Acad Sci U S A Date: 2017-09-18 Impact factor: 11.205
Authors: Janine G Smit; Jenneke C Kasius; Marinus J C Eijkemans; Carolien A M Koks; Ronald van Golde; Annemiek W Nap; Gabrielle J Scheffer; Petra A P Manger; Annemieke Hoek; Benedictus C Schoot; Arne M van Heusden; Walter K H Kuchenbecker; Denise A M Perquin; Kathrin Fleischer; Eugenie M Kaaijk; Alexander Sluijmer; Jaap Friederich; Ramon H M Dykgraaf; Marcel van Hooff; Leonie A Louwe; Janet Kwee; Corry H de Koning; Ineke C A H Janssen; Femke Mol; Ben W J Mol; Frank J M Broekmans; Helen L Torrance Journal: Lancet Date: 2016-04-27 Impact factor: 79.321