| Literature DB >> 34780173 |
Chanté Muller1, Diane L Lynch1, Dow P Hurst1, Patricia H Reggio1.
Abstract
The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a unique, peripheral binding site via extended MD simulations. These results aim to expand the understanding of TRPV1 and assist in the development of new TRPV1 modulators.Entities:
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Year: 2021 PMID： 34780173 DOI： 10.1021/acs.jcim.1c00893
Source DB: PubMed Journal: J Chem Inf Model ISSN： 1549-9596 Impact factor: 4.956