Miaoyuan Lin1, Jibin Yang1, Wenqiang Yan2, Ning Hu3, Ziming Liu2, Li Zhang1, Yuwan Li2. 1. Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563000, P.R.China. 2. Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, 100191, P.R.China. 3. Department of Joint Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400019, P.R.China.
Abstract
OBJECTIVE: To summarize the research progress of tissue engineering technology to promote bone tissue revascularization in osteonecrosis of the femoral head (ONFH). METHODS: The relevant domestic and foreign literature in recent years was extensively reviewed. The mechanism of femoral head vascularization and the application progress of tissue engineering technology in the promotion of ONFH bone tissue revascularization were summarized. RESULTS: Rebuilding or improving the blood supply of the femoral head is the key to the treatment of ONFH. Tissue engineering is a hot spot in current research. It mainly focuses on the three elements of seed cells, scaffold materials, and angiogenic growth factors, combined with three-dimensional printing technology and drug delivery systems to promote the revascularization of the femoral bone tissue. CONCLUSION: The strategy of revascularization of the femoral head can improve the local blood supply and delay or even reverse the progression of ONFH disease.
OBJECTIVE: To summarize the research progress of tissue engineering technology to promote bone tissue revascularization in osteonecrosis of the femoral head (ONFH). METHODS: The relevant domestic and foreign literature in recent years was extensively reviewed. The mechanism of femoral head vascularization and the application progress of tissue engineering technology in the promotion of ONFH bone tissue revascularization were summarized. RESULTS: Rebuilding or improving the blood supply of the femoral head is the key to the treatment of ONFH. Tissue engineering is a hot spot in current research. It mainly focuses on the three elements of seed cells, scaffold materials, and angiogenic growth factors, combined with three-dimensional printing technology and drug delivery systems to promote the revascularization of the femoral bone tissue. CONCLUSION: The strategy of revascularization of the femoral head can improve the local blood supply and delay or even reverse the progression of ONFH disease.
Entities:
Keywords:
Osteonecrosis of the femoral head; drug delivery system; three-dimensional printing technology; tissue engineering; vascularization
Authors: Nicolas S Piuzzi; Jorge Chahla; John B Schrock; Robert F LaPrade; Cecilia Pascual-Garrido; Michael A Mont; George F Muschler Journal: J Arthroplasty Date: 2017-01-12 Impact factor: 4.757