Haiyan Zhu1, Linlin Wang1, Aiguo Ren1. 1. Institute of Reproductive Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, 100191, P.R.China.
Abstract
OBJECTIVE: To review the research progress on etiology and pathogenesis of spina bifida. METHODS: By consulting relevant domestic and foreign research literature on spina bifida, the classification, epidemic trend, pathogenesis, etiology, prevention and treatment of it were analyzed and summarized. RESULTS: Spina bifida, a common phenotype of neural tube defects, is classified based on the degree and pattern of malformation associated with neuroectodermal involvement and is due to the disturbance of neural tube closure 28 days before embryonic development. The prevalence of spina bifida varies greatly among different ethnic groups and regions, and its etiology is complex. Currently, some spina bifida patients can be prevented by folic acid supplements, and with the improvement of treatment technology, the short-term and long-term survival rate of children with spina bifida has improved. CONCLUSION: The research on the pathogenesis of spina bifida will be based on the refined individual information on exposure, genetics, and complex phenotype, and will provide a theoretical basis for improving prevention and treatment strategies through multidisciplinary cooperation.
OBJECTIVE: To review the research progress on etiology and pathogenesis of spina bifida. METHODS: By consulting relevant domestic and foreign research literature on spina bifida, the classification, epidemic trend, pathogenesis, etiology, prevention and treatment of it were analyzed and summarized. RESULTS: Spina bifida, a common phenotype of neural tube defects, is classified based on the degree and pattern of malformation associated with neuroectodermal involvement and is due to the disturbance of neural tube closure 28 days before embryonic development. The prevalence of spina bifida varies greatly among different ethnic groups and regions, and its etiology is complex. Currently, some spina bifida patients can be prevented by folic acid supplements, and with the improvement of treatment technology, the short-term and long-term survival rate of children with spina bifida has improved. CONCLUSION: The research on the pathogenesis of spina bifida will be based on the refined individual information on exposure, genetics, and complex phenotype, and will provide a theoretical basis for improving prevention and treatment strategies through multidisciplinary cooperation.
Authors: Zhiyong Zhao; Lixue Cao; Erick Hernández-Ochoa; Martin F Schneider; E Albert Reece Journal: Biochem Biophys Res Commun Date: 2019-05-12 Impact factor: 3.575
Authors: Callie A M Atta; Kirsten M Fiest; Alexandra D Frolkis; Nathalie Jette; Tamara Pringsheim; Christine St Germaine-Smith; Thilinie Rajapakse; Gilaad G Kaplan; Amy Metcalfe Journal: Am J Public Health Date: 2015-11-12 Impact factor: 9.308
Authors: J D Cragan; H E Roberts; L D Edmonds; M J Khoury; R S Kirby; G M Shaw; E M Velie; R D Merz; M B Forrester; R A Williamson; D S Krishnamurti; R E Stevenson; J H Dean Journal: MMWR CDC Surveill Summ Date: 1995-08-25