Literature DB >> 34778917

Biological Augments for Acetabular Chondral Defects in Hip Arthroscopy-A Scoping Review of the Current Clinical Evidence.

Johnny Rayes1, Sara Sparavalo1, Ivan Wong2.   

Abstract

PURPOSE OF REVIEW: A wide array of joint-preserving surgical techniques exists in the management of acetabular chondral defects (ACDs). The purpose of this review is to summarize the clinical outcomes of the recent biologics used to treat ACDs during hip arthroscopy. RECENT
FINDINGS: Increasing evidence is available for different biological solutions used in the hip. Studies have shown promising outcomes with minimal complications when using biologics as augmentation to microfracture (MF), including different scaffolds or stem cells, or to enhance autologous chondrocyte implantation (ACI). However, data so far is scarce, and more trials and longer follow-ups are needed to better delineate the appropriate indications and benefits for each technique. Presently, the level of evidence is low, but in general, biologics appear safe and trend toward beneficial compared to standard surgical techniques. Augmented MF is recommended for small to medium ACDs, and matrix-assisted ACI or three-dimensional ACI is recommended for medium to large defects.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Acetabular chondral defects; Augmented microfracture; Hip arthroscopy; Hip biologics; Matrix-assisted autologous chondrocyte implantation; Stem cell therapy

Year:  2021        PMID: 34778917      PMCID: PMC8733143          DOI: 10.1007/s12178-021-09721-8

Source DB:  PubMed          Journal:  Curr Rev Musculoskelet Med        ISSN: 1935-9748


  2 in total

1.  CARGEL Bioscaffold improves cartilage repair tissue after bone marrow stimulation in a minipig model.

Authors:  K Hede; B B Christensen; M L Olesen; J S Thomsen; C B Foldager; M C Lind
Journal:  J Exp Orthop       Date:  2020-05-08

2.  Hyaluronic Acid Supplement as a Chondrogenic Adjuvant in Promoting the Therapeutic Efficacy of Stem Cell Therapy in Cartilage Healing.

Authors:  Chin-Chean Wong; Shi-Da Sheu; Pei-Chun Chung; Yi-Yen Yeh; Chih-Hwa Chen; Yen-Wei Chang; Tzong-Fu Kuo
Journal:  Pharmaceutics       Date:  2021-03-23       Impact factor: 6.321

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.