Literature DB >> 34778897

Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+ T-cells promotes their mechanotransduction and activation.

Rui Li1,2, Walida Ali1, Chao Ma1,2, Apratim Bajpai2, Ngoc Luu1, Aarushi Varshney1, Camden Riley Rowe1, Weiqiang Chen1,2,3.   

Abstract

We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

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Year:  2021        PMID： 34778897      PMCID： PMC8877873          DOI： 10.1039/d1cc05194f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

Review 1.  Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse.

Authors:  John A Hammer; Jia C Wang; Mezida Saeed; Antonio T Pedrosa
Journal:  Annu Rev Immunol       Date:  2018-12-21       Impact factor: 28.527

2.  Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing.

Authors:  Roshni Basu; Benjamin M Whitlock; Julien Husson; Audrey Le Floc'h; Weiyang Jin; Alon Oyler-Yaniv; Farokh Dotiwala; Gregory Giannone; Claire Hivroz; Nicolas Biais; Judy Lieberman; Lance C Kam; Morgan Huse
Journal:  Cell       Date:  2016-02-25       Impact factor: 41.582

3.  Micropatterned soft hydrogels to study the interplay of receptors and forces in T cell activation.

Authors:  Jingnan Zhang; Renping Zhao; Bin Li; Aleeza Farrukh; Markus Hoth; Bin Qu; Aránzazu Del Campo
Journal:  Acta Biomater       Date:  2020-10-21       Impact factor: 8.947

Review 4.  Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.

Authors:  Guoyou Huang; Fei Li; Xin Zhao; Yufei Ma; Yuhui Li; Min Lin; Guorui Jin; Tian Jian Lu; Guy M Genin; Feng Xu
Journal:  Chem Rev       Date:  2017-10-09       Impact factor: 60.622

Review 5.  T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance.

Authors:  Robert J Salmond; Andrew Filby; Ihjaaz Qureshi; Stefano Caserta; Rose Zamoyska
Journal:  Immunol Rev       Date:  2009-03       Impact factor: 12.988

6.  CD28 and CD3 have complementary roles in T-cell traction forces.

Authors:  Keenan T Bashour; Alexander Gondarenko; Haoqian Chen; Keyue Shen; Xin Liu; Morgan Huse; James C Hone; Lance C Kam
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-27       Impact factor: 11.205

Review 7.  Advanced biomaterials for cancer immunotherapy.

Authors:  Fan Yang; Kun Shi; Yan-Peng Jia; Ying Hao; Jin-Rong Peng; Zhi-Yong Qian
Journal:  Acta Pharmacol Sin       Date:  2020-03-02       Impact factor: 6.150

Review 8.  Mechanotransduction in T Cell Development, Differentiation and Function.

Authors:  Muaz Rushdi; Kaitao Li; Zhou Yuan; Stefano Travaglino; Arash Grakoui; Cheng Zhu
Journal:  Cells       Date:  2020-02-05       Impact factor: 6.600

9.  Synthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration.

Authors:  Rui Li; Sien Lin; Meiling Zhu; Yingrui Deng; Xiaoyu Chen; Kongchang Wei; Jianbin Xu; Gang Li; Liming Bian
Journal:  Sci Adv       Date:  2019-10-16       Impact factor: 14.136

10.  Multiple actin networks coordinate mechanotransduction at the immunological synapse.

Authors:  Daniel Blumenthal; Janis K Burkhardt
Journal:  J Cell Biol       Date:  2020-02-03       Impact factor: 10.539
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