Literature DB >> 34778775

Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK.

Ronel Müller1, Tiaan M Gerwel2, Magambo Phillip Kimuda3, Özlem Tastan Bishop3, Clinton G L Veale1, Heinrich C Hoppe4.   

Abstract

HPPK, which directly precedes DHPS in the folate biosynthetic pathway, is a promising but chronically under-exploited anti-microbial target. Here we report the identification of new S. enterica HPPK inhibitors, offering potential for new resistance circumventing S. enterica therapies as well as avenues for diversifying the current HPPK inhibitor space. This journal is © The Royal Society of Chemistry.

Entities:  

Year:  2021        PMID： 34778775      PMCID： PMC8528203          DOI： 10.1039/d1md00237f

Source DB:  PubMed          Journal:  RSC Med Chem        ISSN： 2632-8682


  36 in total

Review 1.  The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery.

Authors:  Alun Bermingham; Jeremy P Derrick
Journal:  Bioessays       Date:  2002-07       Impact factor: 4.345

2.  AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.

Authors:  Oleg Trott; Arthur J Olson
Journal:  J Comput Chem       Date:  2010-01-30       Impact factor: 3.376

3.  AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR.

Authors:  R A Laskowski; J A Rullmannn; M W MacArthur; R Kaptein; J M Thornton
Journal:  J Biomol NMR       Date:  1996-12       Impact factor: 2.835

4.  Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies.

Authors:  G Shi; J Blaszczyk; X Ji; H Yan
Journal:  J Med Chem       Date:  2001-04-26       Impact factor: 7.446

5.  Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Authors:  Matthew L Dennis; Sandeep Chhabra; Zhong-Chang Wang; Aaron Debono; Olan Dolezal; Janet Newman; Noel P Pitcher; Raphael Rahmani; Ben Cleary; Nicholas Barlow; Meghan Hattarki; Bim Graham; Thomas S Peat; Jonathan B Baell; James D Swarbrick
Journal:  J Med Chem       Date:  2014-11-12       Impact factor: 7.446

Review 6.  Invasive non-Typhi Salmonella disease in Africa.

Authors:  Susan C Morpeth; Habib O Ramadhani; John A Crump
Journal:  Clin Infect Dis       Date:  2009-08-15       Impact factor: 9.079

Review 7.  Antimicrobials for treating symptomatic non-typhoidal Salmonella infection.

Authors:  Ifeanyi A Onwuezobe; Philip O Oshun; Chibuzo C Odigwe
Journal:  Cochrane Database Syst Rev       Date:  2012-11-14

8.  Structure and activity of Yersinia pestis 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as a novel target for the development of antiplague therapeutics.

Authors:  Jaroslaw Blaszczyk; Yue Li; Scott Cherry; Jerry Alexandratos; Yan Wu; Gary Shaw; Joseph E Tropea; David S Waugh; Honggao Yan; Xinhua Ji
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2007-10-17

9.  The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa.

Authors:  Se Eun Park; Gi Deok Pak; Peter Aaby; Yaw Adu-Sarkodie; Mohammad Ali; Abraham Aseffa; Holly M Biggs; Morten Bjerregaard-Andersen; Robert F Breiman; John A Crump; Ligia Maria Cruz Espinoza; Muna Ahmed Eltayeb; Nagla Gasmelseed; Julian T Hertz; Justin Im; Anna Jaeger; Leon Parfait Kabore; Vera von Kalckreuth; Karen H Keddy; Frank Konings; Ralf Krumkamp; Calman A MacLennan; Christian G Meyer; Joel M Montgomery; Aissatou Ahmet Niang; Chelsea Nichols; Beatrice Olack; Ursula Panzner; Jin Kyung Park; Henintsoa Rabezanahary; Raphaël Rakotozandrindrainy; Emmanuel Sampo; Nimako Sarpong; Heidi Schütt-Gerowitt; Arvinda Sooka; Abdramane Bassiahi Soura; Amy Gassama Sow; Adama Tall; Mekonnen Teferi; Biruk Yeshitela; Jürgen May; Thomas F Wierzba; John D Clemens; Stephen Baker; Florian Marks
Journal:  Clin Infect Dis       Date:  2016-03-15       Impact factor: 9.079

10.  The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Authors:  Penchit Chitnumsub; Aritsara Jaruwat; Yuwadee Talawanich; Krittikar Noytanom; Benjamas Liwnaree; Sinothai Poen; Yongyuth Yuthavong
Journal:  FEBS J       Date:  2020-01-19       Impact factor: 5.542
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