R Baral1, L B Shrestha1, N Ortuño-Gutiérrez2, P Pyakure1,3, B Rai1, S P Rimal1, S Singh1, S K Sharma1, B Khanal1, K Selvaraj4, A M V Kumar5,6,7. 1. BP Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal. 2. Damien Foundation Belgium, Brussels, Belgium. 3. School of Public Health and Community Medicine, BPKIHS, Dharan, Nepal. 4. All India Institute of Medical Sciences, Nagpur, India. 5. International Union Against Tuberculosis and Lung Disease (The Union), Paris, France. 6. The Union South-East Asia Office, New Delhi, India. 7. Yenepoya Medical College, Yenepoya (deemed University), Mangaluru, India.
Abstract
SETTING: There are concerns about the occurrence of multidrug resistance (MDR) in patients with urine tract infections (UTI) in Nepal. OBJECTIVE: To determine culture positivity, trends in MDR among Escherichia coli and Klebsiella pneumoniae infections and seasonal changes in culture-positive UTI specimens isolated from 2014 to 2018 at the B P Koirala Institute of Health Sciences, Dharan, Eastern Nepal. DESIGN: This was a cross-sectional study using secondary laboratory data. RESULTS: Among 116,417 urine samples tested, 19,671 (16.9%) were culture-positive, with an increasing trend in the number of samples tested and culture positivity. E. coli was the most common bacteria (54.3%), followed by K. pneumoniae (8.8%). Among E. coli and K. pneumoniae isolates, MDR was found in respectively 42.5% and 36.0%. MDR was higher in males and people aged >55 years, but showed a decreasing trend over the years. The numbers of isolates increased over the years, with a peak always observed from July to August. CONCLUSION: Low culture positivity is worrying and requires further work into improving diagnostic protocols. Decreasing trends in MDR are a welcome sign. Information on seasonal changes that peak in July-August can help laboratories better prepare for this time with adequate buffer stocks to ensure culture and antibiotic susceptibility testing.
SETTING: There are concerns about the occurrence of multidrug resistance (MDR) in patients with urine tract infections (UTI) in Nepal. OBJECTIVE: To determine culture positivity, trends in MDR among Escherichia coli and Klebsiella pneumoniae infections and seasonal changes in culture-positive UTI specimens isolated from 2014 to 2018 at the B P Koirala Institute of Health Sciences, Dharan, Eastern Nepal. DESIGN: This was a cross-sectional study using secondary laboratory data. RESULTS: Among 116,417 urine samples tested, 19,671 (16.9%) were culture-positive, with an increasing trend in the number of samples tested and culture positivity. E. coli was the most common bacteria (54.3%), followed by K. pneumoniae (8.8%). Among E. coli and K. pneumoniae isolates, MDR was found in respectively 42.5% and 36.0%. MDR was higher in males and people aged >55 years, but showed a decreasing trend over the years. The numbers of isolates increased over the years, with a peak always observed from July to August. CONCLUSION: Low culture positivity is worrying and requires further work into improving diagnostic protocols. Decreasing trends in MDR are a welcome sign. Information on seasonal changes that peak in July-August can help laboratories better prepare for this time with adequate buffer stocks to ensure culture and antibiotic susceptibility testing.
Authors: A Rosello; K B Pouwels; M Domenech DE Cellès; E VAN Kleef; A C Hayward; S Hopkins; J V Robotham; T Smieszek; L Opatowski; S R Deeny Journal: Epidemiol Infect Date: 2017-11-23 Impact factor: 4.434