Literature DB >> 3477792

Biosynthesis of vitamin B12: concerning the origin of the methine protons of the corrin nucleus.

A I Scott1, M Kajiwara, P J Santander.   

Abstract

13C NMR spectroscopy has been used to locate six deuterium atoms incorporated biosynthetically on the periphery of the corrin nucleus of vitamin B12 (cyanocobalamin) derived from cells of Propionibacterium shermanii grown in a medium containing 50% 2H2O and 13C-enriched delta-aminolevulinic acid. The implications of these results for the mechanism of vitamin B12 biosynthesis are discussed, and it is concluded that the same oxidation level of the intermediates is maintained throughout the biosynthetic pathway, from delta-aminolevulinic acid to corrin.

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Year:  1987        PMID： 3477792      PMCID： PMC299133          DOI： 10.1073/pnas.84.19.6616

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  6 in total

1.  Biosynthesis of corrins. I. Experiments with 14-C porphobilinogen and 14-C uroporphyrinogens.

Authors:  A I Scott; C A Townsend; K Okada; M Kajiwara
Journal:  J Am Chem Soc       Date:  1974-12-25       Impact factor: 15.419

2.  Concerning the biosynthesis of vitamin B12.

Authors:  A I Scott; C A Townsend; K Okada; M Kajiwara
Journal:  Trans N Y Acad Sci       Date:  1973-01

3.  Stereochemistry of methyl group insertion in corrinoid biosynthesis. Determination of carbon isotope chirality by 13C nuclear magnetic resonance.

Authors:  A I Scott; C A Townsend; R J Cushley
Journal:  J Am Chem Soc       Date:  1973-08-22       Impact factor: 15.419

4.  Biosynthesis of vitamin B12: mode of incorporation of factor III into cobyrinic acid.

Authors:  C Nussbaumer; M Imfeld; G Wörner; G Müller; D Arigoni
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

5.  Ring contraction of hydroporphinoid to corrinoid complexes.

Authors:  V Rasetti; A Pfaltz; C Kratky; A Eschenmoser
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

6.  Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle.

Authors:  A R Battersby; M J Bushell; C Jones; N G Lewis; A Pfenninger
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205
  6 in total
  4 in total

1.  Biosynthesis of vitamin B12: factor IV, a new intermediate in the anaerobic pathway.

Authors:  A I Scott; N J Stolowich; J Wang; O Gawatz; E Fridrich; G Müller
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

Review 2.  Before enzymes and templates: theory of surface metabolism.

Authors:  G Wächtershäuser
Journal:  Microbiol Rev       Date:  1988-12

3.  Biosynthesis of vitamin B12: isolation of precorrin-6x, a metal-free precursor of the corrin macrocycle retaining five S-adenosylmethionine-derived peripheral methyl groups.

Authors:  D Thibaut; L Debussche; F Blanche
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

4.  Purification and characterization of S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase from Pseudomonas denitrificans.

Authors:  F Blanche; L Debussche; D Thibaut; J Crouzet; B Cameron
Journal:  J Bacteriol       Date:  1989-08       Impact factor: 3.490
  4 in total

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