| Literature DB >> 34774980 |
Ryan N Sheehy1, Luis J Quintanilla2, Juan Song3.
Abstract
The adult dentate gyrus (DG) of the hippocampal formation is a specialized region of the brain that creates new adult-born neurons from a pool of resident adult neural stem and progenitor cells (aNSPCs) throughout life. These aNSPCs undergo epigenetic and epitranscriptomic regulation, including 3D genome interactions, histone modifications, DNA modifications, noncoding RNA mechanisms, and RNA modifications, to precisely control the neurogenic process. Furthermore, the specialized neurogenic niche also uses epigenetic mechanisms in mature neurons and glial cells to communicate signals to direct the behavior of the aNSPCs. Here, we review recent advances of epigenetic regulation in aNSPCs and their surrounding niche cells within the adult DG.Entities:
Keywords: Adult neurogenesis; Dentate gyrus; Epigenetics; Epitranscriptomics; Hippocampus; Learning and memory; Neural stem cells
Mesh：
Year: 2021 PMID： 34774980 PMCID： PMC8691367 DOI： 10.1016/j.neulet.2021.136343
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046