Literature DB >> 3477097

DSLINK: a computer program for gene-centromere linkage analysis in families with a trisomic offspring.

S L Halloran, A Chakravarti.   

Abstract

Trisomic individuals provide information for gene-centromere mapping, since two of the four chromatids in a meiotic tetrad can be recovered. When centromeric markers are available, linkage analysis between the centromere and any marker locus can be performed in nuclear families having one or more trisomic offspring. Since conventional linkage programs consider only disomic individuals, we have written a FORTRAN computer program, DSLINK, that performs gene-centromere linkage analysis on the basis of information on trisomic and disomic offspring. This program makes it possible to study the relationship between recombination and chromosome segregation.

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Year:  1987        PMID： 3477097      PMCID： PMC1684185     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  6 in total

1.  Tests of hypotheses on recombination frequencies.

Authors:  N E Morton; C J MacLean; R Lew
Journal:  Genet Res       Date:  1985-06       Impact factor: 1.588

2.  Multilocus recombination frequencies.

Authors:  N E Morton; C J MacLean
Journal:  Genet Res       Date:  1984-08       Impact factor: 1.588

Review 3.  Trisomy in man.

Authors:  T J Hassold; P A Jacobs
Journal:  Annu Rev Genet       Date:  1984       Impact factor: 16.830

4.  Estimating distances from the centromere by means of benign ovarian teratomas in man.

Authors:  J Ott; D Linder; B K McCaw; E W Lovrien; F Hecht
Journal:  Ann Hum Genet       Date:  1976-11       Impact factor: 1.670

5.  A mapping function for man.

Authors:  D C Rao; N E Morton; J Lindsten; M Hultén; S Yee
Journal:  Hum Hered       Date:  1977       Impact factor: 0.444

6.  The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity.

Authors:  S E Hodge; C E Anderson; K Neiswanger; R S Sparkes; D L Rimoin
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025
  6 in total
  2 in total

1.  The probability of detecting the origin of nondisjunction of autosomal trisomies.

Authors:  A Chakravarti
Journal:  Am J Hum Genet       Date:  1989-05       Impact factor: 11.025

2.  Multipoint estimation of genetic maps for human trisomies with one parent or other partial data.

Authors:  E Feingold; A S Brown; S L Sherman
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025
  2 in total

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