Literature DB >> 34767189

Emerging Role of Non-coding RNAs in Autism Spectrum Disorder.

Soudeh Ghafouri-Fard1, Rezvan Noroozi2, Serge Brand3, Bashdar Mahmud Hussen4, Reyhane Eghtedarian5, Mohammad Taheri6,7, Kaveh Ebrahimzadeh8.   

Abstract

Autism spectrum disorders (ASD) embrace a diverse set of neurodevelopmental diseases with a multifaceted genetic basis. Non-coding RNAs (ncRNAs) are among putative loci with critical participation in the development of ASD. Expression of some lncRNAs, namely RP11-466P24.2, SYP-AS1, STXBP5-AS1, and IFNG-AS1 has been decreased in ASD, while AK128569, CTD-2516F10.2, MSNP1AS, RPS10P2-AS1, LINC00693, LINC00689, NEAT1, TUG1, and Shank2-AS lncRNAs have been over-expressed in ASD. Expression of several miRNAs which are implicated in the immunological developmental, immune responses, and protein synthesis as well as those participating in the regulation of PI3K/Akt/mTOR and EGFR signaling pathways is dysregulated in the context of ASD. In the present article, we describe investigations which appraised the role of lncRNAs, miRNAs, and circRNAs in the pathobiology of ASD.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Autism spectrum disorder; circRNA; lncRNA; miRNA

Mesh：

Substances：

Year:  2021        PMID： 34767189     DOI： 10.1007/s12031-021-01934-3

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  47 in total

1.  Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation.

Authors:  Simone Berkel; Christian R Marshall; Birgit Weiss; Jennifer Howe; Ralph Roeth; Ute Moog; Volker Endris; Wendy Roberts; Peter Szatmari; Dalila Pinto; Michael Bonin; Angelika Riess; Hartmut Engels; Rolf Sprengel; Stephen W Scherer; Gudrun A Rappold
Journal:  Nat Genet       Date:  2010-05-16       Impact factor: 38.330

Review 2.  General hallmarks of microRNAs in brain evolution and development.

Authors:  Wei Chen; Chuan Qin
Journal:  RNA Biol       Date:  2015       Impact factor: 4.652

3.  Codes, conscience and conflicts: ethical dilemmas in midwifery practice.

Authors:  J Gregg
Journal:  Midwives Chron       Date:  1987-12

4.  Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology.

Authors:  Simone Berkel; Wannan Tang; Mario Treviño; Miriam Vogt; Horst Andreas Obenhaus; Peter Gass; Stephen Wayne Scherer; Rolf Sprengel; Gerhard Schratt; Gudrun Anna Rappold
Journal:  Hum Mol Genet       Date:  2011-10-12       Impact factor: 6.150

5.  Co-expression of long non-coding RNAs and autism risk genes in the developing human brain.

Authors:  Steven B Cogill; Anand K Srivastava; Mary Qu Yang; Liangjiang Wang
Journal:  BMC Syst Biol       Date:  2018-12-14

6.  The Long Noncoding RNA RPS10P2-AS1 Is Implicated in Autism Spectrum Disorder Risk and Modulates Gene Expression in Human Neuronal Progenitor Cells.

Authors:  Stephanie M Bilinovich; Kristy Lewis; Nicole Grepo; Daniel B Campbell
Journal:  Front Genet       Date:  2019-10-15       Impact factor: 4.599

7.  Genome-wide, integrative analysis of circular RNA dysregulation and the corresponding circular RNA-microRNA-mRNA regulatory axes in autism.

Authors:  Yen-Ju Chen; Chia-Ying Chen; Te-Lun Mai; Chih-Fan Chuang; Yu-Chen Chen; Sachin Kumar Gupta; Laising Yen; Yi-Da Wang; Trees-Juen Chuang
Journal:  Genome Res       Date:  2020-03-03       Impact factor: 9.043

8.  Aberrant expression of long non-coding RNAs (lncRNAs) is involved in brain glioma development.

Authors:  Yi Ding; Xinfa Wang; Junchen Pan; Minjun Ji; Zhengxiang Luo; Penglai Zhao; Yansong Zhang; Gang Wang
Journal:  Arch Med Sci       Date:  2019-12-31       Impact factor: 3.318

Review 9.  MicroRNAs as regulators of brain function and targets for treatment of epilepsy.

Authors:  Gary P Brennan; David C Henshall
Journal:  Nat Rev Neurol       Date:  2020-06-16       Impact factor: 42.937

Review 10.  MicroRNAs: Not "Fine-Tuners" but Key Regulators of Neuronal Development and Function.

Authors:  Gregory M Davis; Matilda A Haas; Roger Pocock
Journal:  Front Neurol       Date:  2015-11-24       Impact factor: 4.003
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  3 in total

1.  Assessment of Expression of Regulatory T Cell Differentiation Genes in Autism Spectrum Disorder.

Authors:  Mohammadarian Akbari; Reyhane Eghtedarian; Bashdar Mahmud Hussen; Solat Eslami; Mohammad Taheri; Seyedeh Morvarid Neishabouri; Soudeh Ghafouri-Fard
Journal:  Front Mol Neurosci       Date:  2022-07-04       Impact factor: 6.261

2.  Multiple Recurrent Copy Number Variations (CNVs) in Chromosome 22 Including 22q11.2 Associated with Autism Spectrum Disorder.

Authors:  Safiah Alhazmi; Maryam Alzahrani; Reem Farsi; Mona Alharbi; Khloud Algothmi; Najla Alburae; Magdah Ganash; Sheren Azhari; Fatemah Basingab; Asma Almuhammadi; Amany Alqosaibi; Heba Alkhatabi; Aisha Elaimi; Mohammed Jan; Hesham M Aldhalaan; Aziza Alrafiah; Aisha Alrofaidi
Journal:  Pharmgenomics Pers Med       Date:  2022-07-20

Review 3.  The emerging role of long non-coding RNAs in schizophrenia.

Authors:  Guangxian Wu; Xinzhe Du; Zexuan Li; Yanhong Du; Jinzhi Lv; Xinrong Li; Yong Xu; Sha Liu
Journal:  Front Psychiatry       Date:  2022-09-26       Impact factor: 5.435
  3 in total

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