Literature DB >> 34765081

Protein Kinase D: A Potential Therapeutic Target in Prostate Cancer.

Adhiraj Roy1, Q Jane Wang1.   

Abstract

Protein kinase D (PKD) belongs to a family of serine/threonine kinases in the calcium/calmodulin-dependent kinase superfamily. It modulates a number of signal transduction pathways involved in regulation of cell proliferation, survival, migration, angiogenesis, regulation of gene expression, and protein/membrane trafficking, mediated by variety of stimuli such as growth factors, hormones, and cellular stresses. Although its role in cancer progression remains elusive, current literature supports a potential tumor promoting function of the selective PKD isoforms in prostate cancer, making them promising therapeutic targets for cancer treatment.

Entities:  

Keywords:  Prostate cancer; Protein kinase D; Signal transduction; Therapeutic target

Year:  2017        PMID： 34765081      PMCID： PMC8580385     

Source DB:  PubMed          Journal:  Mol Cell Pharmacol        ISSN： 1938-1247


  29 in total

1.  A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D.

Authors:  Heike Döppler; Peter Storz; Jing Li; Michael J Comb; Alex Toker
Journal:  J Biol Chem       Date:  2005-02-22       Impact factor: 5.157

Review 2.  Protein kinase D signaling: multiple biological functions in health and disease.

Authors:  Enrique Rozengurt
Journal:  Physiology (Bethesda)       Date:  2011-02

3.  Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail.

Authors:  Cheng Du; Chuanyou Zhang; Sazzad Hassan; Md Helal Uddin Biswas; K C Balaji
Journal:  Cancer Res       Date:  2010-10-12       Impact factor: 12.701

4.  Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.

Authors:  J L Zugaza; J Sinnett-Smith; J Van Lint; E Rozengurt
Journal:  EMBO J       Date:  1996-11-15       Impact factor: 11.598

5.  Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis.

Authors:  Chang Hoon Ha; Weiye Wang; Bong Sook Jhun; Chelsea Wong; Angelika Hausser; Klaus Pfizenmaier; Timothy A McKinsey; Eric N Olson; Zheng-Gen Jin
Journal:  J Biol Chem       Date:  2008-03-10       Impact factor: 5.157

Review 6.  Mitogenic signaling pathways induced by G protein-coupled receptors.

Authors:  Enrique Rozengurt
Journal:  J Cell Physiol       Date:  2007-12       Impact factor: 6.384

7.  Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cells.

Authors:  James Sinnett-Smith; Elena Zhukova; Nena Hsieh; Xiaohua Jiang; Enrique Rozengurt
Journal:  J Biol Chem       Date:  2004-02-12       Impact factor: 5.157

8.  PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-κB- and HDAC1-mediated expression and activation of uPA.

Authors:  Zhipeng Zou; Fangyin Zeng; Wanfu Xu; Chunxia Wang; Zhiyong Ke; Q Jane Wang; Fan Deng
Journal:  J Cell Sci       Date:  2012-07-13       Impact factor: 5.285

9.  Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase.

Authors:  H Yamamoto; N Oue; A Sato; Y Hasegawa; H Yamamoto; A Matsubara; W Yasui; A Kikuchi
Journal:  Oncogene       Date:  2010-01-18       Impact factor: 9.867

10.  A targeted library screen reveals a new inhibitor scaffold for protein kinase D.

Authors:  Manuj Tandon; Lirong Wang; Qi Xu; Xiangqun Xie; Peter Wipf; Qiming Jane Wang
Journal:  PLoS One       Date:  2012-09-18       Impact factor: 3.240
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  1 in total

Review 1.  Targeting Protein Kinases and Epigenetic Control as Combinatorial Therapy Options for Advanced Prostate Cancer Treatment.

Authors:  Soghra Bagheri; Mahdie Rahban; Fatemeh Bostanian; Fatemeh Esmaeilzadeh; Arash Bagherabadi; Samaneh Zolghadri; Agata Stanek
Journal:  Pharmaceutics       Date:  2022-02-25       Impact factor: 6.321
  1 in total

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