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Literature DB >> 34762896

Genetic Code Expansion Through Quadruplet Codon Decoding.

Abstract

Noncanonical amino acid mutagenesis has emerged as a powerful tool for the study of protein structure and function. While triplet nonsense codons, especially the amber codon, have been widely employed, quadruplet codons have attracted attention for the potential of creating additional blank codons for noncanonical amino acids mutagenesis. In this review, we discuss methodologies and applications of quadruplet codon decoding in genetic code expansion both in vitro and in vivo.

Entities: Chemical

Keywords: +1 frameshift; four-base codon; genetic code; non-canonical amino acids; quadruplet codon

Mesh：

Substances：

Year: 2021 PMID： 34762896 PMCID： PMC9018476 DOI： 10.1016/j.jmb.2021.167346

Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 6.151

79 in total

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Authors: J Christopher Anderson; Thomas J Magliery; Peter G Schultz
Journal: Chem Biol Date: 2002-02

2. Fluorescence resonance energy transfer between unnatural amino acids in a structurally modified dihydrofolate reductase.

Authors: Raymond D Anderson; Jia Zhou; Sidney M Hecht
Journal: J Am Chem Soc Date: 2002-08-21 Impact factor: 15.419

Review 3. Translational accuracy and the fitness of bacteria.

Authors: C G Kurland
Journal: Annu Rev Genet Date: 1992 Impact factor: 16.830

Review 4. Expanding the genetic code.

Authors: Lei Wang; Jianming Xie; Peter G Schultz
Journal: Annu Rev Biophys Biomol Struct Date: 2006

5. A bacterial strain with a unique quadruplet codon specifying non-native amino acids.

Authors: Abhishek Chatterjee; Marc J Lajoie; Han Xiao; George M Church; Peter G Schultz
Journal: Chembiochem Date: 2014-05-27 Impact factor: 3.164

6. An efficient system for incorporation of unnatural amino acids in response to the four-base codon AGGA in Escherichia coli.

Authors: Byeong Sung Lee; Suyeon Kim; Byoung Joon Ko; Tae Hyeon Yoo
Journal: Biochim Biophys Acta Gen Subj Date: 2017-02-14 Impact factor: 3.770

7. Four-base codons ACCA, ACCU and ACCC are recognized by frameshift suppressor sufJ.

Authors: L Bossi; J R Roth
Journal: Cell Date: 1981-08 Impact factor: 41.582

8. Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids.

Authors: Daniel L Dunkelmann; Julian C W Willis; Adam T Beattie; Jason W Chin
Journal: Nat Chem Date: 2020-05-29 Impact factor: 24.427

Genetic Code Expansion Through Quadruplet Codon Decoding.

1. Exploring the limits of codon and anticodon size.

2. Fluorescence resonance energy transfer between unnatural amino acids in a structurally modified dihydrofolate reductase.

Review 3. Translational accuracy and the fitness of bacteria.

Review 4. Expanding the genetic code.

5. A bacterial strain with a unique quadruplet codon specifying non-native amino acids.

6. An efficient system for incorporation of unnatural amino acids in response to the four-base codon AGGA in Escherichia coli.

7. Four-base codons ACCA, ACCU and ACCC are recognized by frameshift suppressor sufJ.

8. Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids.

9. Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs.

10. Using a quadruplet codon to expand the genetic code of an animal.

1. Unleashing the potential of noncanonical amino acid biosynthesis to create cells with precision tyrosine sulfation.

Review 2. Expanding the chemical diversity of M13 bacteriophage.

3. Noncanonical amino acid mutagenesis in response to recoding signal-enhanced quadruplet codons.