Akash Deep1,2, Satoshi Nagakawa3, Pierre Tissieres4,5,6. 1. Paediatric Intensive Care Unit, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK. akash.deep@nhs.net. 2. Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK. akash.deep@nhs.net. 3. Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan. 4. Paediatric Intensive Care, AP-HP Paris Saclay University, Bicêtre Hospital, Le Kremlin-Bicêtre, France. 5. Institute of Integrative Biology of the Cell, CNRS, CEA, Paris Saclay University, Gif-sur-Yvette, France. 6. FHU Sepsis, AP-HP, Paris Saclay University, Inserm, Le Kremlin-Bicêtre, France.