Literature DB >> 34759374

An online GPCR structure analysis platform.

Albert J Kooistra1, Christian Munk2,3, Alexander S Hauser2, David E Gloriam4.   

Abstract

We present an online, interactive platform for comparative analysis of all available G-protein coupled receptor (GPCR) structures while correlating to functional data. The comprehensive platform encompasses structure similarity, secondary structure, protein backbone packing and movement, residue-residue contact networks, amino acid properties and prospective design of experimental mutagenesis studies. This lets any researcher tap the potential of sophisticated structural analyses enabling a plethora of basic and applied receptor research studies.
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Year:  2021        PMID： 34759374     DOI： 10.1038/s41594-021-00675-6

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  2 in total

1.  Conformational plasticity of the intracellular cavity of GPCR-G-protein complexes leads to G-protein promiscuity and selectivity.

Authors:  Manbir Sandhu; Anja M Touma; Matthew Dysthe; Fredrik Sadler; Sivaraj Sivaramakrishnan; Nagarajan Vaidehi
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-28       Impact factor: 11.205

2.  PDBe: improved findability of macromolecular structure data in the PDB.

Authors:  David R Armstrong; John M Berrisford; Matthew J Conroy; Aleksandras Gutmanas; Stephen Anyango; Preeti Choudhary; Alice R Clark; Jose M Dana; Mandar Deshpande; Roisin Dunlop; Paul Gane; Romana Gáborová; Deepti Gupta; Pauline Haslam; Jaroslav Koča; Lora Mak; Saqib Mir; Abhik Mukhopadhyay; Nurul Nadzirin; Sreenath Nair; Typhaine Paysan-Lafosse; Lukas Pravda; David Sehnal; Osman Salih; Oliver Smart; James Tolchard; Mihaly Varadi; Radka Svobodova-Vařeková; Hossam Zaki; Gerard J Kleywegt; Sameer Velankar
Journal:  Nucleic Acids Res       Date:  2020-01-08       Impact factor: 16.971
  2 in total
  1 in total

1.  The G protein database, GproteinDb.

Authors:  Gáspár Pándy-Szekeres; Mauricio Esguerra; Alexander S Hauser; Jimmy Caroli; Christian Munk; Steven Pilger; György M Keserű; Albert J Kooistra; David E Gloriam
Journal:  Nucleic Acids Res       Date:  2022-01-07       Impact factor: 16.971
  1 in total

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