Literature DB >> 34758101

Clinical Image: Calcinosis cutis universalis in a patient with polymyositis/scleroderma overlap syndrome.

Katie Carbonell1, Nicole Droz1.   

Abstract

Entities:  

Year:  2021        PMID: 34758101      PMCID: PMC8843763          DOI: 10.1002/acr2.11371

Source DB:  PubMed          Journal:  ACR Open Rheumatol        ISSN: 2578-5745


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The patient, a 32‐year‐old woman with a known history of polymyositis/scleroderma overlap, presented for a second opinion regarding subcutaneous nodules. On examination, the patient had extensive subcutaneous painful nodules over multiple areas of the body, including bilateral arms, thighs, and hands. There were no open or ulcerative lesions. Workup demonstrated normal creatine kinase, parathyroid hormone, serum calcium, and serum phosphate levels and normal bone mineral density. Electromyography showed no evidence of active myositis. A frontal projection radiograph demonstrated extensive sheetlike soft tissue calcinosis consistent with calcinosis cutis universalis. Calcinosis cutis describes the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue (1). Five subtypes of calcinosis cutis exist on the basis of the etiology: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. The dystrophic subtype results from tissue trauma or chronic inflammation due to autoimmune connective tissue disorders. Dystrophic calcinosis cutis develops in approximately 25% of patients with systemic sclerosis and 11% to 20% of patients with dermatomyositis (2, 3). Calcinosis cutis universalis, as seen in this patient, is a rare presentation. Two types of calcinosis cutis universalis exist: diffuse deposits along myofascial planes and deep intramuscular tumoral deposits, as seen in this patient (4). Although multiple treatment modalities have been trialed, no effective treatment is known (5).
  5 in total

Review 1.  Calcinosis cutis: part I. Diagnostic pathway.

Authors:  Nadine Reiter; Laila El-Shabrawi; Bernd Leinweber; Andrea Berghold; Elisabeth Aberer
Journal:  J Am Acad Dermatol       Date:  2011-07       Impact factor: 11.527

2.  Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: A review of the literature.

Authors:  Hélène Traineau; Rohit Aggarwal; Jean-Benoît Monfort; Patricia Senet; Chester V Oddis; Carlo Chizzolini; Annick Barbaud; Camille Francès; Laurent Arnaud; François Chasset
Journal:  J Am Acad Dermatol       Date:  2019-07-11       Impact factor: 11.527

Review 3.  Calcinosis in rheumatic diseases.

Authors:  Nina Boulman; Gleb Slobodin; Michael Rozenbaum; Itzhak Rosner
Journal:  Semin Arthritis Rheum       Date:  2005-06       Impact factor: 5.532

4.  Treatment of cutaneous calcinosis in limited systemic sclerosis with minocycline.

Authors:  L P Robertson; R W Marshall; P Hickling
Journal:  Ann Rheum Dis       Date:  2003-03       Impact factor: 19.103

Review 5.  Calcifying disorders of the skin.

Authors:  J S Walsh; J A Fairley
Journal:  J Am Acad Dermatol       Date:  1995-11       Impact factor: 11.527

  5 in total
  2 in total

Review 1.  Calcinosis in systemic sclerosis.

Authors:  Srijana Davuluri; Christian Lood; Lorinda Chung
Journal:  Curr Opin Rheumatol       Date:  2022-08-19       Impact factor: 4.941

2.  Subepidermal Calcified Nodule in a Child With Neurofibromatosis Type 1.

Authors:  Buket Bagci; Cansu Karakas; Murat Gokden
Journal:  Cureus       Date:  2022-03-17
  2 in total

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