Luigi Petramala1, Antonio Concistrè1, Francesco Circosta1, Antonietta Gigante1, Francesca Sarlo2, Mauro Schina3, Maurizio Soldini1, Gino Iannucci3, Rosario Cianci1, Claudio Letizia4. 1. Unit of Secondary Arterial Hypertension, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Policlinico "Umberto I", Viale del Policlinico 155, 00185, Rome, Italy. 2. University Cattolica "Sacro Cuore", Rome, Italy. 3. Department of Clinical, Intenal Medicine, Anesthesiologic and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy. 4. Unit of Secondary Arterial Hypertension, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Policlinico "Umberto I", Viale del Policlinico 155, 00185, Rome, Italy. claudio.letizia@uniroma1.it.
Abstract
INTORDUCTION: Aldosterone is known to play important role in developing cardiovascular, metabolic, renal damage in hypertensive patients. AIM: Aim of study was to evaluate parameters obtained by eco-color Doppler study, as non-invasive and easly performed method in asyntomatic patients with Essential Hypertension (EH) and Primary Aldosteronism (PA), without overt organ damage. METHODS: From April 2019 to March 2020 we consecutively enrolled 73 hypertensive subjects (48 males, 25 women), distinguished in two groups: 30 EH patients (mean age 49.5 ± 18.7 years) and 43 PA patients (mean age 53.1 ± 11.6 years)] [23 with aldosterone-secreting adrenal adenoma (APA), 20 with idiopathic aldosteronism (IHA)]. RESULTS: PA group showed higher renal filtration rate and 24-h urinary excretion of albumin respect to EH; moreover, in PA we found higher Pulsatility Index, altered percentage of Renale Resistance Index, Atrophy Index, and reducted parietal thickness than EH. The correlation study showed that plasma aldosterone were positively correlated with pulsatility index in PA group (right r = 0.35; p < 0.05; left r = 0.36; p < 0.05). CONCLUSION: parameters obtained through the intra-renal eco-color Doppler examination, easly performed and non-invasive, can be useful in the early-stage identification of subclinical microvascular alterations, especially in PA, condition characterized by increased risk of cardio-vascular remodelling and metabolic alterations.
INTORDUCTION: Aldosterone is known to play important role in developing cardiovascular, metabolic, renal damage in hypertensive patients. AIM: Aim of study was to evaluate parameters obtained by eco-color Doppler study, as non-invasive and easly performed method in asyntomatic patients with Essential Hypertension (EH) and Primary Aldosteronism (PA), without overt organ damage. METHODS: From April 2019 to March 2020 we consecutively enrolled 73 hypertensive subjects (48 males, 25 women), distinguished in two groups: 30 EH patients (mean age 49.5 ± 18.7 years) and 43 PA patients (mean age 53.1 ± 11.6 years)] [23 with aldosterone-secreting adrenal adenoma (APA), 20 with idiopathic aldosteronism (IHA)]. RESULTS: PA group showed higher renal filtration rate and 24-h urinary excretion of albumin respect to EH; moreover, in PA we found higher Pulsatility Index, altered percentage of Renale Resistance Index, Atrophy Index, and reducted parietal thickness than EH. The correlation study showed that plasma aldosterone were positively correlated with pulsatility index in PA group (right r = 0.35; p < 0.05; left r = 0.36; p < 0.05). CONCLUSION: parameters obtained through the intra-renal eco-color Doppler examination, easly performed and non-invasive, can be useful in the early-stage identification of subclinical microvascular alterations, especially in PA, condition characterized by increased risk of cardio-vascular remodelling and metabolic alterations.
Authors: L Petramala; G Iacobellis; R Carnevale; C Marinelli; L Zinnamosca; A Concistrè; M Galassi; G Iannucci; P Lucia; P Pignatelli; A Ciardi; F Violi; G De Toma; C Letizia Journal: Horm Metab Res Date: 2016-04-21 Impact factor: 2.936
Authors: Bryan Williams; Giuseppe Mancia; Wilko Spiering; Enrico Agabiti Rosei; Michel Azizi; Michel Burnier; Denis L Clement; Antonio Coca; Giovanni de Simone; Anna Dominiczak; Thomas Kahan; Felix Mahfoud; Josep Redon; Luis Ruilope; Alberto Zanchetti; Mary Kerins; Sverre E Kjeldsen; Reinhold Kreutz; Stephane Laurent; Gregory Y H Lip; Richard McManus; Krzysztof Narkiewicz; Frank Ruschitzka; Roland E Schmieder; Evgeny Shlyakhto; Costas Tsioufis; Victor Aboyans; Ileana Desormais Journal: Eur Heart J Date: 2018-09-01 Impact factor: 29.983
Authors: Paul Milliez; Xavier Girerd; Pierre-François Plouin; Jacques Blacher; Michel E Safar; Jean-Jacques Mourad Journal: J Am Coll Cardiol Date: 2005-04-19 Impact factor: 24.094
Authors: Cosimo Bruni; Edoardo Rosato; Vanessa Maestripieri; Antonietta Gigante; Giulia Tesei; Silvia Bellando-Randone; Serena Guiducci; Marco Chiostri; Khadija El Aoufy; Jelena Blagojevic; Alberto Moggi-Pignone; Amato De Paulis; Daniel E Furst; Maria Boddi; Marco Matucci-Cerinic Journal: Eur J Intern Med Date: 2019-09-17 Impact factor: 4.487
Authors: Teresa M Seccia; Claudio Letizia; Maria L Muiesan; Silvia Lerco; Maurizio Cesari; Valeria Bisogni; Luigi Petramala; Giuseppe Maiolino; Roberta Volpin; Gian Paolo Rossi Journal: J Hypertens Date: 2020-02 Impact factor: 4.844
Authors: Emilio Quaia; Jean Michel Correas; Maithili Mehta; John T Murchison; Antonio Giulio Gennari; Edwin J R van Beek Journal: Ultrasound Q Date: 2018-12 Impact factor: 1.657
Authors: Xiao Lin; Muhammad Hasnain Ehsan Ullah; Xiong Wu; Feng Xu; Su-Kang Shan; Li-Min Lei; Ling-Qing Yuan; Jun Liu Journal: Front Cardiovasc Med Date: 2022-02-02